Efficacy of Hepatitis B Virus Vaccines HBVaxpro40© and Fendrix© in Patients with Chronic Liver Disease in Clinical Practice [PDF]
Vaccines, 2022 Chronic liver disease results in a low response rate to the hepatitis B virus vaccine. Information on the efficacy of the double adjuvanted vaccine FENDRIX® (3-O-desacyl-4’-monophosphoryl lipid A and aluminum phosphate) and single adjuvant HBVAXPRO®40 ...
Diana Horta +7 more
doaj +2 more sources
Indian Journal of Dermatology, 2022 Pyoderma gangrenosum (PG) is an uncommon, idiopathic, neutrophilic dermatosis characterised by large necrotic ulcers. Occasionally, patients develop atypical presentations, including pustular, bullous, and vegetative lesions. Bullous pyoderma gangrenosum
Patricia Garcia-Abellas +5 more
doaj +2 more sources
Trichocystatin-2 from Trichomonas vaginalis: role of N-terminal cysteines in aggregation, protease inhibition, and trichomonal cysteine protease-dependent cytotoxicity on HeLa cells [PDF]
Frontiers in ParasitologyTrichomonas vaginalis is a protozoan parasite that causes trichomoniasis, the most common nonviral neglected sexually transmitted disease worldwide. Biomarkers and therapeutic targets, including specific trichomonad cysteine proteases (CPs) and their ...
Verónica Aranda-Chan +5 more
doaj +2 more sources
HLA-DRB1 allele distribution in Chilean population: insights into rheumatoid arthritis susceptibility and protection [PDF]
Frontiers in ImmunologyIntroductionRheumatoid arthritis (RA) is an autoimmune disease influenced by genetic factors, particularly HLA-DRB1 alleles. The objective of this study was to characterize the distribution of HLA-DRB1 alleles in Chilean RA patients and healthy controls (
Diego Catalán +11 more
doaj +2 more sources
Impact of disease burden and late loss of B cell aplasia on the risk of relapse after CD19 chimeric antigen receptor T Cell (Tisagenlecleucel) infusion in pediatric and young adult patients with relapse/refractory acute lymphoblastic leukemia: role of B-cell monitoring [PDF]
Frontiers in Immunology, 2023 IntroductionLoss of B-cell aplasia (BCA) is a well-known marker of functional loss of CD19 CAR-T. Most relapses and loss of BCA occur in the first months after CD19 CAR-T infusion. In addition, high tumor burden (HTB) has shown to have a strong impact on
Águeda Molinos-Quintana +17 more
doaj +2 more sources
Sustained oxygen-releasing hydrogel implants enhance flap regeneration by promoting mitochondrial biogenesis under mild hypoxia [PDF]
Bioactive MaterialsIn regenerative medicine, effective management of tissue ischemia in surgical skin flaps is crucial, yet challenging, particularly because inadequate blood flow often leads to necrosis at the distal flap tips.
Sungmi Jeon +12 more
doaj +2 more sources
Molecular diagnosis of Chagas disease: a systematic review and meta-analysis [PDF]
Infectious Diseases of Poverty, 2023 Background The complexity of the Chagas disease and its phases is impossible to have a unique test for both phases and a lot of different epidemiological scenarios.
Guillermo Pascual-Vázquez +8 more
doaj +2 more sources
HealthData@MAD-R&I: Protocol for Design and Development of a Regional Health Data Infrastructure to Enable Secondary Use of Health Data in Research and Innovation [PDF]
JMIR Research ProtocolsBackgroundThe exponential growth of electronic health records (EHRs), together with the recent entry into force of the European Health Data Space (EHDS) Regulation, highlights the urgent need for secure, interoperable environments
Montserrat León-García +19 more
doaj +2 more sources
Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionDysbiosis is a key mechanism in inflammatory bowel disease (IBD) pathophysiology. Previous microbiota studies in IBD generally have involved patients treated with immunosuppressive agents, which can affect the results.
Macarena Orejudo +41 more
doaj +2 more sources
Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study [PDF]
Antimicrobial Resistance and Infection ControlBackground Infections caused by KPC-producing Klebsiella pneumoniae (KPC-KP) represent a persistent public health challenge. This prospective study examines ten-year trends, clinical features, and genomic epidemiology of hospital-onset (HOI) and non ...
Manuel Recio-Rufián +23 more
doaj +2 more sources