EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2-Mediated µ-Opioid Receptor Internalization. [PDF]
Adv Sci (Weinh)Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Peng B +7 more
europepmc +2 more sources
Magnetic-Field-Tuned Spin-Dependent D-Band and Bifunctionality in L1<sub>0</sub>-FeCoPt for Enhanced Methanol Oxidation. [PDF]
Adv Sci (Weinh)The d‐band center and bifunctional mechanism jointly regulate the amounts of adsorbed OH* and CO*, thereby enhancing electrocatalytic performance, while the application of an external magnetic field further boosts this performance. ABSTRACT The spin‐dependent electronic structure of transition‐metal alloys plays a key role in tuning the magnetic‐field ...
Mo Q +6 more
europepmc +2 more sources
Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of Ca<sup>2</sup> <sup>+</sup>-CaMK-CREB Signaling in Ventral Tegmental Dopaminergic Neurons. [PDF]
Adv Sci (Weinh)Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Jiang H +15 more
europepmc +2 more sources
Decoding the Neural Circuit Underlying Context-Cue Association in Retrieval of Morphine Reward Memory. [PDF]
Adv Sci (Weinh)Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Shi Z +8 more
europepmc +2 more sources
Archaeologia Historica, 2023 Hroby s větším počtem zemřelých, jednoznačně pohřbených v krátkém časovém období (hromadné hroby), jsou spojovány obvykle s oběťmi válečných konfliktů. V poslední době se větší pozornost věnuje hrobům s oběťmi epidemií nebo hladomoru. Připsat je bezpečně
Hana Brzobohatá +2 more
doaj +1 more source
Spoken and Unspoken Matters Regarding the Use of Opioids in Cancer
Journal of Pain Research, 2022 Janna Baker Rogers,1 Gerald M Higa2 1Sections of Geriatrics, Palliative Medicine and Hospice, Department of Medicine, School of Medicine, West Virginia University, Morgantown, WV, USA; 2Departments of Clinical Pharmacy and Medicine, Schools of Pharmacy ...
Baker Rogers J, Higa GM
doaj
New provincial records of the genus Limnonectes (Amphibia, Anura, Dicroglossidae) from South Central, Vietnam [PDF]
Biodiversity Data JournalLimnonectes is one of the poorly-known genera of amphibians in Vietnam. In the herpetofaunal list of Vietnam in 2009, only five species of the genus Limnonectes were recorded from the country. Recently, four new species (L. nguyenorum, L. quangninhensis,
Vien Nguyen +6 more
doaj +3 more sources
Other works of Serigne Mor Kayre [PDF]
, 2012 The entire manuscript is available for download below as a single PDF file. Because of the large size of this manuscript, it is also available in two PDF files. In addition, each page is available as a separate, larger, JPG file.
Serigne Mor Kayre
core +1 more source
Using Deciduous Branch Wood and Conifer Spindle Wood to Manufacture Panels with Transverse Structure
BioResources, 2022 The increasing demand on the wood market makes it necessary to use all secondary resources, including the wood branches and spindles. The properties of deciduous branches and softwood spindles were evaluated in order to create wood panels, highlighting ...
Alin M. Olarescu +2 more
doaj +2 more sources
Kekakuan dan Kekuatan Lentur Maksimum Balok Glulam dan Utuh Kayu Akasia
Jurnal Teknik Sipil, 2008 Glulam merupakan salah satu metoda mengatasi keterbatasan dimensi bahan dasar kayu yang tersedia. Dengan mempersiapkan lamina-lamina dan menyusunnya serta melakukan proses perekatan antar permukaan lamina dapat menghasilkan dimensi balok sesuai ...
Indah Sulistyawati +3 more
doaj +1 more source