Results 161 to 170 of about 762,520 (384)

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

The Morality of Euthanasia [PDF]

open access: yes, 2019
In this paper, I defend the view that the requested euthanasia of adults is morally permissible and should be legalised; I use an argument from analogy which compares physician-assisted euthanasia with morally less ambiguous and, in my opinion, an ...
Greif, Adam
core  

Why Machines Can't Be Moral: Turing's Halting Problem and the Moral Limits of Artificial Intelligence [PDF]

open access: yesarXiv
In this essay, I argue that explicit ethical machines, whose moral principles are inferred through a bottom-up approach, are unable to replicate human-like moral reasoning and cannot be considered moral agents. By utilizing Alan Turing's theory of computation, I demonstrate that moral reasoning is computationally intractable by these machines due to ...
arxiv  

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

Visual moral inference and communication [PDF]

open access: yesarXiv
Humans can make moral inferences from multiple sources of input. In contrast, automated moral inference in artificial intelligence typically relies on language models with textual input. However, morality is conveyed through modalities beyond language. We present a computational framework that supports moral inference from natural images, demonstrated ...
arxiv  

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

From Stability to Inconsistency: A Study of Moral Preferences in LLMs [PDF]

open access: yesarXiv
As large language models (LLMs) increasingly integrate into our daily lives, it becomes crucial to understand their implicit biases and moral tendencies. To address this, we introduce a Moral Foundations LLM dataset (MFD-LLM) grounded in Moral Foundations Theory, which conceptualizes human morality through six core foundations.
arxiv  

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