Results 171 to 180 of about 762,520 (384)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Labour justice and sustainable tourism: the centrality of equity as a sustainability principle [PDF]

open access: yes, 2009
What we value is intricately linked to our morality and our ethics, whether personal or corporate. Sustainability is essentially a statement of morality, embeddlng as it does the notion of inter- and intra-generational equity, This includes, among other ...
Chok, S., Macbeth, J.
core   +1 more source

MORALITAS ANAK DAN KAITANNYA DENGAN URGENSI PENDIDIKAN ISLAM

open access: yesLentera Pendidikan: Jurnal Ilmu Tarbiyah dan Keguruan, 2007
The morality issues always colored human life from the changing of time. The basic principle of morality is identically with character or ethics. These terms have similar meaning, those are; habit, character, and disposition.
Syarifuddin Ondeng
doaj  

Editor's Introduction

open access: yesThe Baltic International Yearbook of Cognition, Logic and Communication, 2012
Philosophers investigate the nature of morality. And scientists study the moral judgments people make, the moral norms people enforce, and the systems of moral rules people embrace. What is the relationship between these investigations?
Michael Bishop
doaj   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Economic Analysis of Welfare Economics, Morality and the Law [PDF]

open access: yes
This paper contains the chapters on welfare economics, morality, and the law from a general, forthcoming book, Foundations of Economic Analysis of Law (Harvard University Press, 2003).
Steven Shavell
core  

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