Results 181 to 190 of about 762,520 (384)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

What is become of the rights of men? : are you the only men who have rights? ; moral contractarianism and the legitimation of universal human rights [PDF]

, 2012
In this article I advance an account of human rights as individual claims that can be justified within the conceptual framework of social contract theories. The contractarian approach at issue here aims, initially, at a justification of morality at large,
Araujo, Marcelo de
core  

…Politics and Mere Morality [PDF]

, 1968
Johnston Sean F.
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Morality and Mere Politics… [PDF]

, 1968

openalex   +1 more source

Holding Robots Responsible: The Elements of Machine Morality

Trends in Cognitive Sciences, 2019
Yochanan E. Bigman, A. Waytz, R. Alterovitz, Kurt Gray   +3 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Are Rules Meant to be Broken? Understanding Multilingual Moral Reasoning as a Computational Pipeline with UniMoral [PDF]

arXiv
Moral reasoning is a complex cognitive process shaped by individual experiences and cultural contexts and presents unique challenges for computational analysis. While natural language processing (NLP) offers promising tools for studying this phenomenon, current research lacks cohesion, employing discordant datasets and tasks that examine isolated ...
arxiv  

The Aesthetic Element in Morality, and its place in a Utilitarian Theory of Morals.

, 1893
John Watson, Frank Chapman Sharp
openalex   +2 more sources

MORALITY ON THE CAMPUS [PDF]

, 1968
Wilford E. Smith
openalex   +1 more source