Results 51 to 60 of about 785,945 (409)

On Gellman's Attempted Rescue [PDF]

open access: yes, 2010
In "Ordinary Morality Implies Atheism" (2009), I argued that traditional theism threatens ordinary morality by relieving us of any moral obligation to prevent horrific suffering by innocent people even when we easily can.
Maitzen, Stephen
core   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Moraliteit, die opdringerige en die voorwaardelike

open access: yesKoers : Bulletin for Christian Scholarship, 2010
Morality, the obtrusive and the conditional The secularist (immanentist), historicist and pluralistic nature of current thinking disables the articulation of transcendental conditions for morality.
M.F. Heyns
doaj   +1 more source

The evolution of morality and the end of economic man [PDF]

open access: yes, 2014
1871 saw the publication of two major treatises in economics, with self-seeking economic man at their center. In the same year Darwin published The Descent of Man, which emphasized sympathy and cooperation as well as self-interest, and contained a ...
Hodgson, G.M.
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Braintrust: What Neuroscience Tells Us About Morality

open access: yesEurope's Journal of Psychology, 2018
Europe's Journal of Psychology, 2018, Vol. 14(2), 515–518, doi:10.5964/ejop.v14i2.1589 Published (VoR): 2018-06-19. *Corresponding author at: Human Cognition Laboratory, School of Psychology, University of Minho, 4710 – 057 Braga, Portugal.
F. Pazhoohi
semanticscholar   +1 more source

Ethics and morality in Dworkin's political philosophy [PDF]

open access: yes, 2012
Dworkin`s political theory is characterized by the interpretative integrity of morality, law, and politics, the so-called “hedgehog’s approach”. The interpretative integrity approach functions on multiple levels. Firstly, philosophical foundations of his
Vujadinović, Dragica
core  

Patient-Relativity in Morality [PDF]

open access: yes, 2016
It is common to distinguish moral rules, reasons, or values that are agent-relative from those that are agent-neutral. One can also distinguish moral rules, reasons, or values that are moment-relative from those that are moment-neutral.
Hammerton, Matthew
core   +2 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

„A to se vyplatí!“ Morálka jako spolupráce?

open access: yesReflexe, 2021
The article is a polemics with those conceptions of the nature of morality which, based on an inquiry into the evolutionary origins of morality, locate its meaning in a society’s cooperation (backed by rules) for the purpose of joint success.
Ondřej Beran
doaj   +1 more source

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