Results 51 to 60 of about 2,517,806 (274)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Play\u27s the Thing : Considering the Morality Play in Morality Play [PDF]
, 2006 The paucity of details about secular theater in the fourteenth century allows Barry Unsworth to imagine what a troupe of players would look like if we could examine them right at the time when a totally new form of drama was being born (Unsworth ...
McDonald, Heather Kennedy
core +1 more source
Proscriptive versus prescriptive morality : Two faces of moral regulation [PDF]
, 2009 A distinction is made between two forms of morality on the basis of approach–avoidance differences in self-regulation. Prescriptive morality is sensitive to positive outcomes, activation-based, and focused on what we should do.
Sana Sheikh +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
This rapid review brings together recent research, grey literature, lived experience and practice examples to examine play in and around UK schools today.
Russell, Wendy K +3 more
core +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Morality and the politics of Shakespeare’s Macbeth
Literator, 1987 When morality is defined in terms of moral theology, and politics in the pragmatic terms of gaining and retaining power, the two concepts as they are developed in Shakespeare’s Macbeth are not mutually incompatible but mutually interdependent.
E. Lickindorf
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The Psychology of Morality [PDF]
, 2018 Five questions regarding the nature of the moral sense, the origin of conscience, the development of morality, variability in the moral sense, and the relation of morality to behavior are examined from the point of view of four theoretical approaches ...
Diane Sunar, Sunar, Diane
core +1 more source