Results 31 to 40 of about 1,289,189 (314)

Hybrid Minimally Invasive Esophagectomy vs. Open Esophagectomy: A Retrospective Propensity Score Matched Comparison

Medicina, 2023
Background and Objectives: Though widely used, only limited data is available that shows the superiority of hybrid minimally-invasive esophagectomy (HMIE) compared to open esophagectomy (OE).
Anna Vincke, Sorin Miftode, Fadl Alfarawan, Maximilian Bockhorn, Nader El-Sourani   +4 more
doaj   +1 more source

Morbidity in Depressive Disorders [PDF]

Psychotherapy and Psychosomatics, 2017
Levels of residual morbidity in mood disorder patients followed up long-term under community conditions of treatment are remarkably high [1] . Both unipolar major depressive disorder (MDD) and bipolar disorder (BD) patients were ill 40–50% of follow-up time; in BD patients, three-quarters of that residual morbidity was depressive [1] .
Baldessarini, Ross J., Forte, Alberto, Selle, Valerio, Sim, Kang, Tondo, Leonardo, Undurraga, Juan, Vázquez, Gustavo H.   +6 more
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Comparing Predictors and Outcomes of Higher Allostatic Load across Zoo-Housed African Great Apes

Journal of Zoological and Botanical Gardens, 2023
Stressors over the lifespan can contribute to physiological dysregulation, or allostatic load. Allostatic load has been studied in humans using allostatic load indices (ALIs) for over 25 years, but the same methods are rarely applied to other species. We
Ashley N. Edes, Katie L. Edwards, Dawn Zimmerman, Balbine Jourdan, Douglas E. Crews, Barbara A. Wolfe, Donald L. Neiffer, Janine L. Brown   +7 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Genome-Wide DNA methylation profile analysis identifies differentially methylated loci associated with personal PM2.5 exposure in adults with asthma

Ecotoxicology and Environmental Safety
Particulate matter with aerodynamic diameters ≤2.5 µm (PM2.5) is a major environmental risk factor for acute asthma exacerbation, and the underlying mechanism is not completely understood.
Ruirui Duan, Hongtao Niu, Linxi Ma, Ting Yang   +3 more
doaj   +1 more source

Preoperative nutritional support in patients undergoing pancreatic surgery affects PREPARE score accuracy

Frontiers in Surgery, 2023
BackgroundThis study aimed to validate the accuracy of the Preoperative Pancreatic Resection (PREPARE) risk score in pancreatic resection patients.Patients and methodsThis prospective study included 216 patients who underwent pancreatic resection between
Pavel Skalicky, Katerina Knapkova, Jana Tesarikova, Michal Gregorik, Dusan Klos, Martin Lovecek   +5 more
doaj   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Efficiency of Electricity Production Technology from Post-Process Gas Heat: Ecological, Economic and Social Benefits

Energies, 2020
The strengthening of ecological conflicts due to the increase of the destructive impact from industrial companies on the environment provokes the development and implementation of the eco-innovation technologies.
Radosław Miśkiewicz
doaj   +1 more source

Robot-Assisted Radical Cystectomy: A Single-Center Experience and a Narrative Review of Recent Evidence

Diagnostics, 2023
Radical cystectomy represents one of the most challenging surgical procedures, exhibiting a high morbidity rate. The transition to minimally invasive surgery in the field has been steep, due to either the technical complexity and prior concerns of ...
Bernardo Rocco, Giulia Garelli, Simone Assumma, Filippo Turri, Mattia Sangalli, Tommaso Calcagnile, Giorgia Gaia, Stefano Terzoni, Guglielmo Oliviero, Daniele Stroppa, Enrico Panio, Luca Sarchi, Alberto del Nero, Giorgio Bozzini, Angelica Grasso, Paolo Dell’Orto, Maria Chiara Sighinolfi   +16 more
doaj   +1 more source