Results 61 to 70 of about 3,157,480 (392)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Impact of the 2011 Libyan conflict on road traffic injuries in Benghazi, Libya [PDF]

Libyan Journal of Medicine, 2015
Background: Road traffic injuries (RTIs) are a major public health concern in Libya. In the light of the armed conflict in Libya that broke out on February 2011 and the subsequent instability, the rate and pattern of RTIs was studied.
Zuhir Bodalal, Riyad Bendardaf, Mohammed Ambarek, Nico Nagelkerke   +3 more
doaj   +1 more source

Mortality and morbidity rates in patients undergoing emergency laparotomy: an analysis in a tertiary care hospital

Asian Journal of Medical Sciences, 2022
Background: Emergency Laparotomy is a complex and often time-critical surgical procedure associated with significant morbidity and mortality. Emergency abdominal surgery is performed in most hospitals, and acute laparotomy is considered a high-risk ...
Manoj P , Shashikumar HB , Fathimath Shihana   +2 more
doaj   +1 more source

Cannabis and depression: A twin model approach to co-morbidity [PDF]

, 2017
Cannabis use disorder (CUD) co-occurs with major depressive disorder (MDD) more frequently than would be expected by chance. However, studies to date have not produced a clear understanding of the mechanisms underlying this co-morbidity.
Agrawal, A., Bergin, J. E, Lynskey, M. T, Martin, N. G, Morley, K. I, Nelson, E. C, Rijsdijk, F., Smolkina, M., Statham, D.   +8 more
core   +4 more sources

Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.

New England Journal of Medicine, 1991
BACKGROUND AND METHODS In the Cardiac Arrhythmia Suppression Trial, designed to test the hypothesis that suppression of ventricular ectopy after a myocardial infarction reduces the incidence of sudden death, patients in whom ventricular ectopy could be ...
D. Echt, P. Liebson, L. Mitchell, R. Peters, D. Obias-Manno, A. H. Barker, D. Arensberg, A. Baker, Lawrence M. Friedman, H. Greene, M. Huther, D. Richardson   +11 more
semanticscholar   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Perceived vocal morbidity in a problem asthma clinic [PDF]

, 2009
<p>Aims: Asthma treatment has the potential to affect patients' voices. We undertook detailed characterisation of voice morbidity in patients attending a problem asthma clinic, and we determined how patients' perceptions related to objective ...
A E Stanton, A McConnachie, Altman, Barnes, C E Bucknall, C Sellars, De Bodt, Dejonckere, Fairbanks, K MacKenzie, Stanton, Stanton, Stanton, Williamson   +13 more
core   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

MiR-23a-5p alleviates chronic obstructive pulmonary disease through targeted regulation of RAGE-ROS pathway

Respiratory Research
Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease and represents the third leading cause of death worldwide. This study aimed to investigate miRNA regulation of Receptor for Advanced Glycation End-products (RAGE), a ...
Chenli Chang, Ke Huang, Xia Xu, Ruirui Duan, Tao Yu, Xu Chu, Chen Chen, Baicun Li, Ting Yang   +8 more
doaj   +1 more source