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Results 241 to 250 of about 5,286,255 (301)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source

Narrative Review of the Role of Nondepolarizing Neuromuscular Blocking Agents in Anesthesia: Perspective 2026. [PDF]

Med Sci Monit
Radkowski P +6 more
europepmc +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton +2 more
wiley +1 more source

BBB dynamics: the lifespan perspective. [PDF]

Sci Rep
Ren XS.
europepmc +1 more source

Book Review: Jule, A. (2019). The compassionate educator: Understanding social issues and the ethics of care in Canadian schools. Toronto, ON: Canadian Scholars. Hardcover, 305 pages, ISBN 978-1-77338-133-6.

, 2020
Belcher, Christina
core

Centring Biodiversity in Nursing for Decolonial Planetary Health. [PDF]

Nurs Inq
Jones AT, Vera M, LeClair J, Harsch D.
europepmc +1 more source

Parental Identity and Subjective Well-Being in Older Women: The Moderating Role of the Human-Dog Bond. [PDF]