Results 81 to 90 of about 2,461,126 (340)

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

English Children Singing: Morning Sammy [PDF]

, 1949
A short song accompanied by a piano.A group of songs performed by children recorded in ...
Robertson, Aileen Margaret
core  

Impact of Intended Isocaloric Early versus Late Time‐Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial

Advanced Science, EarlyView.
Women with overweight or obesity follow intended isocaloric early and late time‐restricted eating (TRE) in a crossover trial. Shotgun plasma lipidomics reveals no significant differences between interventions, but identify pronounced lipid changes—including reductions in ceramides and phosphatidylcholines—within the early TRE.
Kristof Szekely, Mathias J. Gerl, Beeke Peters, Julia Schwarz, Bettina Schuppelius, Markus Damm, Jorge R. Soliz‐Rueda, Ratika Sehgal, Michail Lazaratos, Christian Klose, Kai Simons, Andreas F. H. Pfeiffer, Annette Schürmann, Achim Kramer, Andreas Michalsen, Olga Pivovarova‐Ramich   +15 more
wiley   +1 more source

Waking Up In the Morning (WUIM): A Smart Learning Environment for Students with Learning Difficulties [PDF]

, 2021
Polyxeni Kaimara, Ioannis Deliyannis, Ανδρέας Οικονόμου, Emmanuel Fokides   +3 more
openalex   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

New Life Leads to Linfield [PDF]

, 2005
One cold March morning, 6-year-old Viktoria Putintsev ‘05 left life as she knew it ...
Davis, Laura
core   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

The effects of morning preconditioning protocols on testosterone, cortisol and afternoon sprint cycling performance [conference presentation] [PDF]

, 2018
Opportunities exist for athletes to undertake morning exercise protocols in an attempt to potentate afternoon performance. Four sub elite track sprint cyclists completed a morning cycling (Cyc) or weights-based protocol (WP) prior to an afternoon cycling
Maulder, Peter S, McDonald, Kerin
core  

P1447EARLY MORNING ACCELERATION AND NOCTURNAL DECELERATION IN HEART RATE ASSOCIATE WITH LVH AND THE RISK OF DEATH AND CARDIOVASCULAR EVENTS IN HEMODIALYSIS PATIENTS [PDF]

, 2020
Francesca Mallamaci, Rocco Tripepi, Claudia Torino, Giovanni Tripepi, Marianna Bellantoni, Elvira Puntorieri, Rocco Truglia, Gaetana Porto   +7 more
openalex   +1 more source

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

Advanced Science, EarlyView.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li, Aijun Shen, Xiaolong Gao, Chao Lin, Zongliang Huang, Qi Lv, Junjun Tang, Xiaolong Ma, Jiong Ni, Ju Tian, Jiaqi Wu, Xiaowen Xu, Wei Wang, Peijun Wang   +13 more
wiley   +1 more source