Results 261 to 270 of about 270,592 (355)

The Role of Narcotics (Morphine) in Postoperative Morbidity.

open access: hybrid, 1949
John H. Strickler, Carl O. Rice
openalex   +1 more source

(2R,6R)‐hydroxynorketamine prevents opioid abstinence‐related negative affect and stress‐induced reinstatement in mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder (OUD) is a pressing public health concern marked by frequent relapse during periods of abstinence, perpetuated by negative affective states. Classical antidepressants or the currently prescribed opioid pharmacotherapies have limited efficacy to reverse the negative affect or prevent relapse ...
Andria Michael   +7 more
wiley   +1 more source

Faecal Microbiota Transplantation Modulates Morphine Addictive-Like Behaviours Through Hippocampal Metaplasticity. [PDF]

open access: yesAddict Biol
Saeedi N   +6 more
europepmc   +1 more source

Behavioural and pharmacokinetic analysis of heroin and cocaine self‐administration: Effects of timeout on self‐administration and choice in male rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Heroin and cocaine users tailor their dosage, frequency and administration route to maximise the drugs' effects or prevent withdrawal symptoms. Counterintuitively, preclinical self‐administration and choice experiments employ, almost invariably and regardless of the pharmacokinetic properties of the drug under examination, fixed ...
Ginevra D'Ottavio   +18 more
wiley   +1 more source

Effects of intravenous morphine and lidocaine on bacterial growth. [PDF]

open access: yesBMC Anesthesiol
Osoian CI   +5 more
europepmc   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li   +9 more
wiley   +1 more source

A small molecule PKCε inhibitor reduces hyperalgesia induced by paclitaxel or opioid withdrawal. [PDF]

open access: yesJCI Insight
Gregory-Flores A   +11 more
europepmc   +1 more source

Cannabidiol dose dependently reduces alcohol intake in mice via a non‐5‐HT1A receptor mechanism: Exploration of other potential receptor targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Binge drinking is a risky pattern of alcohol intake and a major predictor of alcohol use disorder (AUD). Current AUD medications have limited efficacy and poor patient compliance, calling for more effective therapeutics.
Connie J. Badolato   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy