Results 301 to 310 of about 235,160 (357)
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Morphine Metabolism and Morphine Tolerance in Goldfish
Anesthesiology, 1970Tolerance to morphine was induced in goldfish shown to be unable to metabolize morphine. Ability to metabolize is, therefore not a prercquisite to development of tolerance.
Nicholas M. Greene, George A. Jansen
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Morphine-Induced Attenuation of Morphine Tolerance
Science, 1981Rats experienced both morphine and an environmental cue, but the cue always signaled a drug-free period. They were subsequently administered morphine in the presence of the cue, and the development of analgesic tolerance was assessed. The prior experience retarded such tolerance.
Krank, Riley E. Hinson, Shepard Siegel
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Morphine and alternative opioids in cancer pain: the EAPC recommendations
British Journal of Cancer, 2001 An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain.
G. Hanks +14 more
exaly +2 more sources
Psychopharmacology, 1976
The morphine blocking and anticonvulsant effects of propranolol were investigated in mice. Three different convulsant procedures (electroshock, pentylenetetrazol and thebaine) were used. In addition, LD50's of morphine after different doses of propranolol were done.
Anatole T. Zuban +2 more
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The morphine blocking and anticonvulsant effects of propranolol were investigated in mice. Three different convulsant procedures (electroshock, pentylenetetrazol and thebaine) were used. In addition, LD50's of morphine after different doses of propranolol were done.
Anatole T. Zuban +2 more
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PLoS ONE, 2013 Opiates are among the most prescribed drugs for pain management. However, morphine use or abuse results in significant gut bacterial translocation and predisposes patients to serious infections with gut origin.
Jingjing Meng +2 more
exaly +2 more sources
CNS Drugs, 2010
Oral morphine/naltrexone extended release capsules comprise the selective mu-opioid receptor agonist morphine in a sustained-release formulation combined with a sequestered core of the mu-opioid receptor antagonist naltrexone for use in the management of moderate to severe pain.
Lesley J. Scott, Sean T. Duggan
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Oral morphine/naltrexone extended release capsules comprise the selective mu-opioid receptor agonist morphine in a sustained-release formulation combined with a sequestered core of the mu-opioid receptor antagonist naltrexone for use in the management of moderate to severe pain.
Lesley J. Scott, Sean T. Duggan
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Journal of the American Chemical Society, 2002
The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was
Arnold L. Rheingold +2 more
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The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was
Arnold L. Rheingold +2 more
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Journal of Pain & Palliative Care Pharmacotherapy, 2012
In conjunction with World Cancer Day 2012, three leading pain and palliative care organizations developed a statement on access to analgesics to provide freedom from pain as a human right. Numerous other professional organizations subsequently signed this manifesto calling upon governments, the pharmaceutical industry, and health institutions to make ...
Palliative Care, Pallium India
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In conjunction with World Cancer Day 2012, three leading pain and palliative care organizations developed a statement on access to analgesics to provide freedom from pain as a human right. Numerous other professional organizations subsequently signed this manifesto calling upon governments, the pharmaceutical industry, and health institutions to make ...
Palliative Care, Pallium India
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Morphine preference in rats previously morphine dependent
Pharmacological Research Communications, 1984Morphine preference and tendency to relapse to morphine tolerance and dependence were studied in rats which were previously made morphine dependent. Tolerance to, and physical dependence on, morphine were initially produced by administration of increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks.
Clive W. Ogle, Soter Dai, S.-C. G. Hui
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Regional Anesthesia and Pain Medicine, 1997
Background and ObjectivesIt has been suggested that the potency of epidural morphine might be explained by spinal metabolism to the active and potent metabolite morphine-6-glucuronide (M6G). The main objective of this study was to describe the early pharmacokinetics of epidurally administered, morphine with special attention to the appearance of the ...
Christina Eintrei +2 more
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Background and ObjectivesIt has been suggested that the potency of epidural morphine might be explained by spinal metabolism to the active and potent metabolite morphine-6-glucuronide (M6G). The main objective of this study was to describe the early pharmacokinetics of epidurally administered, morphine with special attention to the appearance of the ...
Christina Eintrei +2 more
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