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Distribution of Morphine and Morphine Metabolites in Rat Brain [PDF]
Biochemical Society Transactions, 1977 Misra et al. (1971) found that 1 h after a single subcutaneous injection of [N-Me-l4C1morphine into the rat, three radioactive compounds could be extracted from the cerebral cortex, namely free morphine, morphine 3-glucuronide and a ‘non-acid-hydrolysable’ conjugate.
Paul Bullock +2 more
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Unwanted effects of morphine‐6‐glucuronide and morphine
Anaesthesia, 2002Summary The active metabolite of morphine, morphine‐6‐glucuronide (M6G), may have fewer unwanted effects than morphine. We randomly allocated 144 women to receive either M6G or morphine as part of general anaesthesia for day case gynaecological laparoscopy.
T. Milner, B. Ho, C. Cann, J. Curran
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The effects of prenatal morphine on the responsiveness to morphine and amphetamine
Pharmacology Biochemistry and Behavior, 1986The effects of morphine administered to pregnant Sprague-Dawley rats on the schedule-controlled behavior of the offspring were examined. It was observed that both male and female adult rats exposed prenatally to morphine were tolerant to the disruptive effects of morphine on fixed-interval responding compared to age-matched controls.
David S. Gottesfeld +4 more
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Pain, 1994
Recent studies have suggested that morphine-3-glucuronide (M3G) may antagonize the analgesic effects of morphine and morphine-6-glucuronide (M6G). To investigate this hypothesis, steady-state concentrations of morphine, M6G and M3G in serum and cerebrospinal fluid (CSF) were measured in 11 patients receiving chronic morphine therapy (9 orally and 2 ...
Kenneth F. Ilett +2 more
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Recent studies have suggested that morphine-3-glucuronide (M3G) may antagonize the analgesic effects of morphine and morphine-6-glucuronide (M6G). To investigate this hypothesis, steady-state concentrations of morphine, M6G and M3G in serum and cerebrospinal fluid (CSF) were measured in 11 patients receiving chronic morphine therapy (9 orally and 2 ...
Kenneth F. Ilett +2 more
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2005
Abstract Morphine is the main pharmacologically active constituent of opium, the resin derived from the dried juice of the opium poppy, Papaver sominferum. Morphine was first introduced into clinical practice more than 200 years ago. Its effects are mediated by activating opioid receptors, mainly within the central nervous system (CNS ...
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Abstract Morphine is the main pharmacologically active constituent of opium, the resin derived from the dried juice of the opium poppy, Papaver sominferum. Morphine was first introduced into clinical practice more than 200 years ago. Its effects are mediated by activating opioid receptors, mainly within the central nervous system (CNS ...
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Science, 1970
The development of a radioimmunoassay for morphine is described. The hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule. Extremely low concentrations of morphine (0.5 nanogram) can be measured by this assay procedure.
S, Spector, C W, Parker
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The development of a radioimmunoassay for morphine is described. The hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule. Extremely low concentrations of morphine (0.5 nanogram) can be measured by this assay procedure.
S, Spector, C W, Parker
openaire +2 more sources