Results 371 to 380 of about 339,726 (399)
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Journal of the American Chemical Society, 2002
The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was
Arnold L. Rheingold +2 more
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The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was
Arnold L. Rheingold +2 more
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Journal of Pain & Palliative Care Pharmacotherapy, 2012
In conjunction with World Cancer Day 2012, three leading pain and palliative care organizations developed a statement on access to analgesics to provide freedom from pain as a human right. Numerous other professional organizations subsequently signed this manifesto calling upon governments, the pharmaceutical industry, and health institutions to make ...
Palliative Care, Pallium India
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In conjunction with World Cancer Day 2012, three leading pain and palliative care organizations developed a statement on access to analgesics to provide freedom from pain as a human right. Numerous other professional organizations subsequently signed this manifesto calling upon governments, the pharmaceutical industry, and health institutions to make ...
Palliative Care, Pallium India
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Regional Anesthesia and Pain Medicine, 1997
Background and ObjectivesIt has been suggested that the potency of epidural morphine might be explained by spinal metabolism to the active and potent metabolite morphine-6-glucuronide (M6G). The main objective of this study was to describe the early pharmacokinetics of epidurally administered, morphine with special attention to the appearance of the ...
Christina Eintrei +2 more
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Background and ObjectivesIt has been suggested that the potency of epidural morphine might be explained by spinal metabolism to the active and potent metabolite morphine-6-glucuronide (M6G). The main objective of this study was to describe the early pharmacokinetics of epidurally administered, morphine with special attention to the appearance of the ...
Christina Eintrei +2 more
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Distribution of Morphine and Morphine Metabolites in Rat Brain [PDF]
Biochemical Society Transactions, 1977 Misra et al. (1971) found that 1 h after a single subcutaneous injection of [N-Me-l4C1morphine into the rat, three radioactive compounds could be extracted from the cerebral cortex, namely free morphine, morphine 3-glucuronide and a ‘non-acid-hydrolysable’ conjugate.
Paul Bullock +2 more
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Morphine preference in rats previously morphine dependent
Pharmacological Research Communications, 1984Morphine preference and tendency to relapse to morphine tolerance and dependence were studied in rats which were previously made morphine dependent. Tolerance to, and physical dependence on, morphine were initially produced by administration of increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks.
Clive W. Ogle, Soter Dai, S.-C. G. Hui
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The pharmacokinetics of morphine and morphine glucuronides in kidney failure
Clinical Pharmacology and Therapeutics, 1993The pharmacokinetics of morphine and its glucuronide metabolites were investigated in three groups of patients with kidney failure (nondialyzed, receiving dialysis, and transplantation) and compared with a group of normal healthy volunteers. Patients in all three renal groups were undergoing surgical procedures (nondialyzed group undergoing ...
Duncan Trew +4 more
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Journal of the American Medical Association (JAMA), 2013
IMPORTANCE Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such as respiratory depression.
I. Ceelie +9 more
semanticscholar +1 more source
IMPORTANCE Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such as respiratory depression.
I. Ceelie +9 more
semanticscholar +1 more source
Purity Profiles for Heroin, Morphine, and Morphine Hydrochloride
Journal of Pharmaceutical Sciences, 1973Purity profiles were established for samples of heroin (diacetylmorphine), morphine, and morphine hydrochloride in order to define the scope of utility of each as qualitative and/or quantitative analytical standards. Systems for solubility analysis and high-pressure liquid chromatography were investigated. A heroin synthesis affording a product of high
Lee T. Grady +2 more
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Unwanted effects of morphine‐6‐glucuronide and morphine
Anaesthesia, 2002Summary The active metabolite of morphine, morphine‐6‐glucuronide (M6G), may have fewer unwanted effects than morphine. We randomly allocated 144 women to receive either M6G or morphine as part of general anaesthesia for day case gynaecological laparoscopy.
T. Milner, B. Ho, C. Cann, J. Curran
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The effects of prenatal morphine on the responsiveness to morphine and amphetamine
Pharmacology Biochemistry and Behavior, 1986The effects of morphine administered to pregnant Sprague-Dawley rats on the schedule-controlled behavior of the offspring were examined. It was observed that both male and female adult rats exposed prenatally to morphine were tolerant to the disruptive effects of morphine on fixed-interval responding compared to age-matched controls.
David S. Gottesfeld +4 more
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