Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
The Patterns of Altitudinal Gradient Differentiation in the Morphological Traits of <i>Calliptamus italicus</i> (L.) (Orthoptera: Acridoidea) and Their Environmental Driving Mechanisms in the Desert Steppe in the Ili River Basin. [PDF]
Abulaiti A +12 more
europepmc +1 more source
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
A Multivariate CT-Based Model for Differentiating Styloid Syndrome From Asymptomatic Styloid Elongation: A Retrospective Comparative Study of Positional and Morphological Parameters. [PDF]
Wang Y, Yang Z.
europepmc +1 more source
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Distinct Morphological Progression Patterns in Primary Versus Recurrent Pterygium: Vertical Attenuation Versus Deep Stromal Invasion. [PDF]
Yun YI, Ha DH, Lee SH, Kim KW.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Expanded character sampling inspired by a new Cretaceous conifer seed cone from California: importance of morphology in resolving relationships among the Cupressaceae. [PDF]
Pfeiler KC +5 more
europepmc +1 more source

