Results 101 to 110 of about 4,124,133 (335)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Morphological plasticity and adaptation level of distylous Primula nivalis in a heterogeneous alpine environment

Plant Diversity, 2018
Plant populations at high elevation face extreme climatic conditions and resource limitations. The existence of distylous species at different elevations can help us investigate their adaptation to high altitudes, the evolution of their morphological ...
Aysajan Abdusalam, Qingjun Li
doaj   +1 more source

CMAF – CHRIS Morphological Adaptive Filter

Ecological Questions, 2013
The paper presents a new method of CHRIS images filtering. The presented algorithm is based on mathematical morphology operations and allows to correct the main CHRIS images noise types, like missing pixels and vertical stripes caused by a malfunctioning of the device. the algorithm is preceded by the brief discussion on the nature of the noise and the
openaire   +2 more sources

(Non)Parallel Evolution [PDF]

, 2018
Parallel evolution across replicate populations has provided evolutionary biologists with iconic examples of adaptation. When multiple populations colonize seemingly similar habitats, they may evolve similar genes, traits, or functions.
Barrett, Rowan DH, Bolnick, Daniel I, Oke, Krista B, Rennison, Diana J, Stuart, Yoel E   +4 more
core  

Scalable Co-Optimization of Morphology and Control in Embodied Machines

, 2017
Evolution sculpts both the body plans and nervous systems of agents together over time. In contrast, in AI and robotics, a robot's body plan is usually designed by hand, and control policies are then optimized for that fixed design.
Bongard, Josh, Cheney, Nick, Lipson, Hod, SunSpiral, Vytas   +3 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Adaptive order morphology edge detection

Journal of Computers, 2012
In this paper, we present an edge detection model by combining order morphology transformation and anti-noise morphology transformation. In the model, we construct three kinds of edge detection operators and apply them in edge detection of some gray images and some urban satellite images with different levels of salt and pepper noise, gaussian noise ...
Yuanni Wang, Fei Ge
openaire   +1 more source

Cross-Lingual Dependency Parsing for Closely Related Languages - Helsinki's Submission to VarDial 2017

, 2017
This paper describes the submission from the University of Helsinki to the shared task on cross-lingual dependency parsing at VarDial 2017. We present work on annotation projection and treebank translation that gave good results for all three target ...
Tiedemann, Jörg
core   +1 more source

Eda haplotypes in three-spined stickleback are associated with variation in immune gene expression [PDF]

, 2017
Haplotypes underlying local adaptation and speciation are predicted to have numerous phenotypic effects, but few genes involved have been identified, with much work to date concentrating on visible, morphological, phenotypes.
A El Nagar, A Smahi, A Zapata, A-L Ducrest, ADC MacColl, ADC MacColl, AK Greenwood, C Cluzeau, C Eizaguirre, C Eizaguirre, C Lexer, CR Linnen, CR Linnen, D Schluter, DJ Rennison, DQ Tran, DV Chan, F Mackay, FC Jones, FC Jones, G Rauch, J De Roij, JP Scharsack, JSC Arthur, KB Marchinko, M Hammer, M Probst-Kepper, MA Bell, MG Mills, MW Pfaffl, NH Barton, O Seehausen, P Brassard, P Nosil, PF Colosimo, PF Colosimo, R Hopkins, RD Barrett, RD Barrett, RD Reed, RDH Barrett, S Robertson, S Robertson, S Wisniewski, S Yeaman, SE Johnston, SE Johnston, SF Owen, T Henrich, TJ Little, Y Sun   +50 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source