Results 71 to 80 of about 4,124,133 (335)

The biomechanical importance of the scaphoid-centrale fusion during simulated knuckle-walking and its implications for human locomotor evolution [PDF]

, 2020
© 2020, The Author(s). Inferring the locomotor behaviour of the last common ancestor (LCA) of humans and African apes is still a divisive issue. An African great-ape-like ancestor using knuckle-walking is still the most parsimonious hypothesis for the ...
Chamberlain, A.T., Marcé-Nogué, J., Püschel, T.A., Sellers, W.I., Yoxall, Alaster   +4 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Unexpected increase in structural integrity caused by thermally induced dwarfism in large benthic foraminifera

Royal Society Open Science
Climate change is predicted to negatively impact calcification and change the structural integrity of biogenic carbonates, influencing their protective function.
Danna Titelboim, Nikita J. Rothwell, Oliver T. Lord, Robert L. Harniman, Leanne A. Melbourne, Daniela N. Schmidt   +5 more
doaj   +1 more source

Microtubule Regulation in Plants: From Morphological Development to Stress Adaptation

Biomolecules, 2023
Microtubules (MTs) are essential elements of the eukaryotic cytoskeleton and are critical for various cell functions. During cell division, plant MTs form highly ordered structures, and cortical MTs guide the cell wall cellulose patterns and thus control
An-Shan Hsiao, Ji-Ying Huang
doaj   +1 more source

Morphological and functional changes in the vertebral column with increasing aquatic adaptation in crocodylomorphs

Royal Society Open Science, 2015
The lineage leading to modern Crocodylia has undergone dramatic evolutionary changes in morphology, ecology and locomotion over the past 200+ Myr. These functional innovations may be explained in part by morphological changes in the axial skeleton, which
J. Molnar, S. Pierce, Bhart‐Anjan S. Bhullar, Alan H. Turner, J. Hutchinson   +4 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Genetic and morphological differentiation in Populus nigra L.: isolation by colonization or isolation by adaptation?

Molecular Ecology, 2015
Identifying processes underlying the genetic and morphological differences among populations is a central question of evolutionary biology. Forest trees typically contain high levels of neutral genetic variation, and genetic differences are often ...
Jennifer Dewoody, H. Trewin, G. Taylor
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Towards the 'green city' concept: Spatio-morphological development resources of small towns in Vojvodina [PDF]

Arhitektura i Urbanizam, 2016
The main idea of this paper is to highlight the spatial and morphological potential of smaller settlements in Vojvodina, for their adaptation and transformation according to the principles of sustainable urban form and the concept of 'green' city ...
Simić Ivan, Mihajlov Vladimir
doaj   +1 more source

Stereo Image Matching Using Adaptive Morphological Correlation

Sensors, 2022
A stereo matching method based on adaptive morphological correlation is presented. The point correspondences of an input pair of stereo images are determined by matching locally adaptive image windows using the suggested morphological correlation that is optimal with respect to an introduced binary dissimilarity-to-matching ratio criterion.
Victor H. Diaz-Ramirez, Martin Gonzalez-Ruiz, Vitaly Kober, Rigoberto Juarez-Salazar   +3 more
openaire   +3 more sources