Results 101 to 110 of about 1,039,654 (308)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Revision of the Global Fauna of Leptochela Stimpson, 1860 (Crustacea: Decapoda), Highlighting Phylogenetic Clades and a New Species

Diversity
Leptochela Stimpson (1860) is a shallow-water, benthopelagic genus within the predominantly pelagic superfamily Pasiphaeoidea. We inventoried a global fauna of 17 currently valid species of Leptochela and identified a newly discovered eighteenth species.
Alexander L. Vereshchaka, Anastasiia A. Lunina, Dmitry N. Kulagin, Jørgen Olesen, Laure Corbari   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Taxonomic revision of the Paepalanthus trichophyllus complex (Poales, Eriocaulaceae) with the description of two new species

European Journal of Taxonomy
We revise the Paepalanthus trichophyllus species complex using multivariate morphological analyses, leading to a redefinition of species boundaries, clarification of nomenclature and taxonomy, and the description of two new species: P.
Lucas Espindola Florêncio da Silva, Marcelo Trovó   +1 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Morphological analyses of two gynandromorphy individuals of Geometridae (Lepidoptera: Geometridae)

SHILAP
In this study, gynandromorphs individuals of Gnopharmia cholcidaria (Lederer, 1870) and Idea adeversaria (Linnaeus, 1758) from Turkey were observed morphologically, compared to each other and normal individuals.
S. Seven, M. Özdemir
doaj   +1 more source

Improving word coverage using unsupervised morphological analyser

Sadhana, 2009
Powerful computers are needed for processing tasks related to human languages these days. Human languages, also called natural languages, are highly versatile systems of encoding information and can capture information of various domains. To enable a computer to process information in human languages, the language needs to be appropriately ‘described ...
K. V. N. Sunitha, N. Kalyani
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Phylogenetics, divergence and morphology of New Zealand Eleotridae (Gobiomorphus Gill) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Ecology at Massey University, Palmerston North, New Zealand [PDF]

, 2006
The genus Gobiomorphus Gill (1863) is the only representative freshwater Eleotridae in New Zealand and is comprised of seven species, of which four are diadromous.
Atkinson, Emily
core