A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Obtaining new resolutions in carnivore tooth pit morphological analyses: A methodological update for digital taphonomy. [PDF]
Courtenay LA +5 more
europepmc +1 more source
A revision of cervid phylogeny using a total evidence approach [PDF]
Asher, Robert J. +4 more
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Phylogenetic and Morphological Analyses Reveal Twelve New Species of the Genus Patellaria (Dothideomycetes, Ascomycota) from Mexico. [PDF]
García-Jacobo I +4 more
europepmc +1 more source
Functional-morphological analyses of the delicate snap-traps of the aquatic carnivorous waterwheel plant (Aldrovanda vesiculosa) with 2D and 3D imaging techniques. [PDF]
Westermeier AS +3 more
europepmc +1 more source
On the phylogenetic position of the hornless pecoran Amphimoschus – an example of arising challenges with the incorporation of fossils in extant combined frameworks [PDF]
Asher, Robert J. +6 more
core +1 more source
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han +8 more
wiley +1 more source
Phase, Chemical, Thermal, and Morphological Analyses of Thermoplastic Polyurethane (TPU) Nanocomposites Reinforced with Jute Cellulose Nanofibers (CNFs). [PDF]
Nordi SS +4 more
europepmc +1 more source
Two Distinct Genotypes of Spissistilus festinus (Say, 1830) (Hemiptera, Membracidae) in the United States Revealed by Phylogenetic and Morphological Analyses. [PDF]
Cieniewicz E +4 more
europepmc +1 more source

