Results 71 to 80 of about 7,310,486 (303)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

WAYS OF IMPROVEMENT OF LIFE QUALITY OF PATIENTS UNDERGOING THYROID SURGERY

Вестник хирургии имени И.И. Грекова, 2015
The authors analyzed quality of life before and after thyroid surgery in 350 patients. The article suggested the ways of improving of surgical treatment by developing some technical details.
T. B. Duboshina, M. P. Askerov, O. A. Zhmyleva   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

USING THE ADAPTIVERANDOARMASKAUGMENTATION FUNCTION FOR MEDICAL IMAGE AUGMENTATION AND MASK INPAINTING WITH DEEP LEARNING

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
The segmentation of medical images via deep learning is troubled by two primary issues: lack of segmented data and difficulty of shapes. Modern approaches for data augmentation have clearly surpassed classical techniques like shifting, rotating and ...
Zainab Adnan Jwad, Israa Hadi Ali
doaj   +1 more source

Morphological operation-based bi-dimensional empirical mode decomposition for automatic background removal of fringe patterns.

Optics Express, 2012
A modified bi-dimensional empirical mode decomposition (BEMD) method is proposed for sparsely decomposing a fringe pattern into two components, namely, a single intrinsic mode function (IMF) and a residue.
Xiaoping Zhou, A. Podoleanu, Zhuangqun Yang, Tao Yang, Hong Zhao   +4 more
semanticscholar   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Morphological gradient operators for colour images [PDF]

2004 International Conference on Image Processing, 2004. ICIP '04., 2005
A new morphological gradient operator for colour images is introduced that can be viewed as a direct extension of the well known morphological gradient. In this approach, each pixel is considered as multivariate data and its output is the maximum distance between any two points within a structuring element, determined by a norm.
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source