Results 61 to 70 of about 537,113 (312)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Simple assessment of spatio-temporal evolution of salt marshes ecological services [PDF]

, 2019
A number of previous research studies have addressed the enormous role played by biodiversity and ecosystems in human well-being and have placed particular emphasis on the consequences of the reduction or loss of these services. A handful of studies have
Baily, Balmford, Balvanera, Barbier, Barbier, Bouma, Carpenter, Carrasco, Caçador, Chang, Chang, Chmura, Costanza, Costanza, Costanza, Crosby, Daily, de Groot, de Groot, Greenberg, Kirwan, Kirwan, Kirwan, Koch, Lovelock, Morris, Murray, Müller-Navarra, Ouyang, Palmer, Redfield, Rieb, Rizzetto, Rova, Santana-Cordero, Schile, Stocker, Torio, Turner, Walls, Wang, Wu, Zhao   +42 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The variety of shapes perianth leafl et of Colchicum laetum L., C. ancyrense B. L. Burtt and C. bulbocodium var. versicolor (Ker Gawl.) K. Perss [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология
The objects of the study were C. laetum L., C. ancyrense B. L. Burtt and C. bulbocodium var. versicolor (Ker Gawl.) K. Pers. The variability of the shape of the bends of the sepals was studied by geometric morphometry.
Epifanov, Vladimir S., Parhomenko, Alena Sergeevna, Kondrateva, Anna Olegovna, Orlowa, Anastasiya D., Kashin, Alexandr Stepanovich   +4 more
doaj   +1 more source

Delimitation of Some Taxa of Ulnaria and Fragilaria (Bacillariophyceae) Based on Genetic, Morphological Data and Mating Compatibility

Diversity, 2023
Fragilaria and Ulnaria are two closely related diatom genera for which the delimitation and circumscription of several species is unclear. We studied strains isolated from Lake Baikal and compared them with the species from freshwater reservoirs in ...
Yulia Zakharova, Artyom Marchenkov, Darya Petrova, Yurij Bukin, Aleksey Morozov, Yekaterina Bedoshvili, Yulia Podunay, Olga Davidovich, Nikolai Davidovich, Alexander Bondar, Maria Kahlert, Yelena Likhoshway   +11 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Modeling the effect of soil meso- and macropores topology on the biodegradation of a soluble carbon substrate [PDF]

, 2015
Soil structure and interactions between biotic and abiotic processes are increasingly recognized as important for explaining the large uncertainties in the outputs of macroscopic SOM decomposition models.
Chenu, Claire, Coquet, Yves, Falconer, Ruth E., Garnier, Patricia, Makowski, David, Nunan, Naoise, Pot, Valérie, Raynaud, Xavier, Vieublé-Gonod, Laure, Vogel, Laure E.   +9 more
core   +5 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Morphological and Molecular Variability of Rhizoctonia solani Isolates Causing Banded Leaf and Sheath Blight in Maize

International Journal of Bio-Resource and Stress Management, 2015
Twenty seven isolates of Rhizoctonia solani causing Banded Leaf and Sheath Blight in maize were collected from different maize varieties and one from rice grown in various regions of Telengana State, India for easy breeding task.
M. Madhavi, P. Narayan Reddy, R. Ranga Reddy, S. Sokka Reddy   +3 more
doaj  

MORPHOLOGICAL VARIABILITY OF PREMOLARS ROOTS

Romanian Journal of Medical and Dental Education, 2020
Aim of the study The successful endodontic therapy is due to the knowledge of the root and canal morphological variability of premolars. The aim of this study is to present this variability of number of roots/canals for the first and second premolars, both upper and lower, and to compare the results with data from literature.
Maria-Antonela Beldiman, Elena Luca, Cristina Iordache, Anca Mihaela Vițalariu, Liana Aminov   +4 more
openaire   +1 more source