Results 71 to 80 of about 537,113 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

¿Es posible caracterizar el espacio fenotípico a partir de las relaciones entre elementos de un plan corporal? Un análisis sistémico en la lagartija Uta stansburiana Is it possible to characterize the phenotypic space from the relationship among the elements of a body plan? A systemic analysis in the lizard Uta stansburiana

Revista Mexicana de Biodiversidad, 2009
Se analizaron las relaciones cuantitativas entre los elementos del plan corporal de Uta stansburiana para evaluar su influencia sobre la estructura y los límites del espacio fenotípico de esta especie.
Juan Rivera, Pedro Miramontes, Fausto Méndez, Daniel Piñero   +3 more
doaj  

Variation in pelvic morphology may prevent the identification of anterior pelvic tilt [PDF]

, 2008
Pelvic tilt is often quantified using the angle between the horizontal and a line connecting the anterior superior iliac spine (ASIS) and the posterior superior iliac spine (PSIS).
Bowker, P, Graham-Smith, P, Herrington, LC, Nester, CJ, Preece, SJ, Willan, P   +5 more
core   +3 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Cotton leaf blight disease caused by Alternaria alternata in Sudan

Journal of Plant Protection Research, 2019
Genetically modified Bt cotton (Gossypium hirsutum) leaves with typical symptoms of Alternaria early blight disease resembling that of tomato and potato were observed in the main cotton growing schemes in Sudan.
Omyma Elmahi Mohamed, Mayada Mamoun Beshir, Nafisa Elmahi Ahmed   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Correlation of Morphological Variables in Germ-Cell Hypoplasia [PDF]

Archives of Andrology, 1987
The correlations between the progression of germ-cell hypoplasia, measured with the Johnsen's score, reduction in tubular diameter, and thickening of the lamina propria of the seminiferous tubules were studied in a series of 42 biopsy specimens of the testis from 26 infertile men.
PESCE, CARLO, A. Reale
openaire   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Diversity analysis of mangosteen (Garcinia mangostana) irradiated by gamma-ray based on morphological and anatomical characteristics [PDF]

, 2010
Tujuan penelitian ini adalah meningkatkan keragaman genetik manggis (Garcinia mangostana L.) yang diiradiasi dengan sinar gamma dosis 0 Gy, 20 Gy, 25 Gy, 30 Gy, 35 Gy dan 40 Gy.
SOBIR,, SUHARTANTO, MUH RAHMAD, WIDIASTUTI, ALFIN   +2 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source