Results 81 to 90 of about 53,870 (244)

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Morpho-anatomical traits of Cysticercus pisiformis in European rabbits (Oryctolagus cu-niculus)

Bulgarian Journal of Veterinary Medicine
The study was conducted in the laboratory of the Department of Parasitology and Veterinary-Sanitary Examination of the Poltava State Agrarian University.
S. Mykhailiutenko, O. Kruchynenko, L. Kuzmenko, O. Klymenko , N. Dmytrenko   +4 more
doaj   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

MORPHOMETRIC PARAMETERS OF MALE FETAL PERINEAL FORMATIONS

Bukovinian Medical Herald
Introduction. In recent years, Ukraine has observed a steady trend towards an increase in the level of congenital pathology of the perineal area. This is mainly manifested in the form of anorectal defects and malformations of the external genitalia, the localization of which topographically corresponds to the excretory and urogenital areas.
openaire   +3 more sources

MORPHOMETRIC PARAMETERS OF ERYTHROCYTES IN SEVERAL RODENTIA SPECIES

Proceedings of the Karelian Research Centre of the Russian Academy of Sciences, 2019
Red blood cells (RBC) play a leading role in the blood gas transport function and oxygen supply to tissues, and the number and size of RBC have a decisive role in tissue oxygenation. The size of erythrocyte varies significantly among animal species, depending  on a number of factors.
Aleksandra Kizhina, Svetlana Sergina, Lyudmila Uzenbaeva, Viktor Ilyukha, Elvira Pechorina, Ekaterina Antonova, Alina Yakimova, Danila Panchenko   +7 more
openaire   +3 more sources

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

Advanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang, Zi‐Han Chen, Jiajia Li, Wei Hu, Ying Cao, Yu Wang, Xiaoyu Tong, Wenhan Lu, Yuze Yang, Yuehao Wang, Yan Xiao, Wenhao Gao, Yuning Chen, Yuyan Hou, Fan Zhang, Yi Feng   +15 more
wiley   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Kinematic Reconstruction of a Deep-Seated Gravitational Slope Deformation by Geomorphic Analyses

Geosciences, 2018
On 4 November 2010, a deep-seated gravitational slope deformation (North Italy) reactivated with sudden ground movement. A 450,000 m2 mountainous area moved some metres downslope, but the undeniable signs were only connected to the triggering of a debris
Stefano Morelli, Veronica Pazzi, William Frodella, Riccardo Fanti   +3 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Length-weight relationship and condition factors of European perch, Perca fluviatilis, from 38 lakes in northeastern Poland

Fisheries & Aquatic Life
Length-weight relationships and condition factors of various fish species depend on food resources, habitat, season, water quality, and the size, age, and sexual maturity of fishes.
Kozłowski Michał, Traczuk Piotr, Kalinowska Krystyna   +2 more
doaj   +1 more source