Results 91 to 100 of about 1,908,985 (246)

Chronic Treatment with a Promnesiant GABA-A 𝜶𝟓-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

Advances in Pharmacological Sciences, 2011
Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors (α5IA) have promnesiant activity.
J. Braudeau, L. Dauphinot, A. Duchon, A. Loistron, R. H. Dodd, Y. Hérault, B. Delatour, M. C. Potier   +7 more
doaj   +1 more source

Global Recommendations for the Use of Diagnostic Genomic Sequencing in the Prenatal Setting on Behalf of the ESHG and ISPD

Prenatal Diagnosis, EarlyView.
Zandra C. Deans, Lina Basel Salmon, Kwong Wai Choy, Guido de Wert, Zirui Dong, Lilian Downie, Francesca Romana Grati, Sabine Hentze, Paula Jorge, Brynn Levy, Luca Lovrecic, Dora Mayen, Álvaro Mendes, Michael Morris, Ashley Pritchard, Raquel Gouveia Silva, Tina‐Marié Wessels, Francesca Forzano, Natalie J. Chandler   +18 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

EFFECTIVENESS OF AN INTERDISCIPLINARY PROGRAM IN PATIENTS WITH FAILED BACK SURGERY SYNDROME

Coluna/Columna
Objective: To evaluate the results of an interdisciplinary program administered to patients with failed back surgery syndrome, aiming at functional improvement, modulation of pain, reduction of anxiety symptoms and depression, and improvement of quality
JOSÉ EDUARDO NOGUEIRA FORNI, ANA MARCIA RODRIGUES CUNHA, CARLOS EDUARDO D'AGLIO ROCHA, LILIAN CHESSA DIAS, MARCO HENRIQUE D'ALL AGLIO FOSS, RANDOLFO DOS SANTOS JUNIOR, GERARDO MARIA DE ARAUJO FILHO, MARIELZA REGINA ISMAEL MARTINS   +7 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Experimental, Quasi‐Experimental, and Single‐Case Family Education Interventions in Special Education in Türkiye: A Systematic Review

Family Relations, EarlyView.
ABSTRACT Objective To systematically review experimental, quasi‐experimental, and single‐case family education interventions conducted in special education in Türkiye between 2020 and 2025. Background Family education is a key component of special education services, yet the characteristics and methodological quality of intervention studies conducted ...
Tuğba Sivrikaya, Hatice Ulu Aydın
wiley   +1 more source

Sertoli cell adenoma in Morris syndrome.

European journal of gynaecological oncology, 1981
An unusually large Sertoli cell adenoma was detected in a patient with Morris syndrome and there is a description of the uncommon hormonal data found in this particular case which are not typical for this kind of neoplasia. The patient is alive and well at the present time which is now three years after surgical intervention.
Moneta E, BENEDETTI PANICI, PIERLUIGI, Sacco F, Pizzolato G.P.   +3 more
openaire   +3 more sources

Assessing the Reliability and Validity of the Catalight Family Wellbeing Scale in a Turkish Sample

Family Relations, EarlyView.
ABSTRACT Background Family well‐being is increasingly recognized as an important outcome in research and practice involving families of individuals with developmental disabilities, highlighting the need for valid assessment instruments. However, the Catalight Family Wellbeing Scale (CFWS) has only been validated in the United States, and evidence for ...
Sedat Turgut, Esra Sözer Boz, Mahir Uğurlu, Lindsey Sneed, Ben Pfingston   +4 more
wiley   +1 more source

Evaluating sexual satisfaction with the modified McIndoe technique in urogenital disorders by Barcelona Scale

Revista Médica del Hospital General de México
Introduction: Mayer-Rokitansky-Ku?ster-Hauser syndrome, also referred to as Mu?llerian aplasia, is a congenital disorder characterized by aplasia of the uterus and upper part of the vagina in females with normal secondary sex characteristics and a normal
Adán Araujo-López, Paulina Cardona-Ochoa, Mónica Gónzalez-Rodríguez, Rogelio Dávila-Portilla, Rodrigo Rueda De León-Serna, Rodolfo L. Ríos-Lara y López, Juan A. Ugalde-Vitelly   +6 more
doaj  

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source