Results 131 to 140 of about 1,908,985 (246)

Comparison of Methods for Incorporating Related Data When Developing Clinical Prediction Models: A Simulation Study

open access: yesBiometrical Journal, Volume 68, Issue 5, October 2026.
ABSTRACT Clinical Prediction Models (CPMs) compute an individual's risk of an outcome, given a set of predictors. Guidance states CPMs should be constructed using data sampled from the target population. However, researchers might have access to ancillary data sets from different time points, countries, or healthcare settings, which could support model
Haya Elayan   +6 more
wiley   +1 more source

Lung‐Cardiovascular Interactions and Derangements in ARDS

open access: yesComprehensive Physiology, Volume 16, Issue 5, October 2026.
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez   +4 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang   +5 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Complete androgen insensitivity (syndrome of Morris): A case

open access: yes, 2015
La feminización testicular es una afección genética recesiva ligada al cromosoma X, con insensibilidad andrógenica completa, siendo la variedad más frecuente de pseudohermafroditismo masculino. La producción de andrógenos por los testículos es normal, pero no hay acción por ausencia de receptores en los órganos diana.
Fajardo, María   +2 more
openaire   +1 more source

Lettre de John Cameron à William Morris sur la nomination de Morris au poste de receveur général

open access: yes
4 pages, originalLettre de John Cameron à William Morris sur : la nomination de Morris [au poste de receveur général]; une rumeur voulant que [John] King recoive un poste de surintendant d'un asile pour aliénés mentaux, malgré une promesse faite
Cameron, John;
core   +1 more source

Lettre de William Gordon à William Morris sur la gratitude des Society Settlers du canton de Lanark envers Morris

open access: yes
4 pages, originalLettre de William Gordon à William Morris sur : la gratitude des Society Settlers du canton de Lanark envers Morris, pour attentions et aide accordées aux colons depuis dix ...
Gordon, William;
core   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

open access: yes
Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
Dunia Hatabah   +5 more
wiley   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

open access: yesNaval Research Logistics (NRL), Volume 73, Issue 7, Page 1141-1158, October 2026.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

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