Results 21 to 30 of about 1,908,985 (246)

Natural substance rutin versus standard drug atorvastatin in a treatment of metabolic syndrome-like condition

Saudi Pharmaceutical Journal, 2019
Background: Metabolic syndrome is a cluster of metabolic risk factors. The clear causes of its development are not known yet and there is no comprehensive treatment of this disease.
Dominika Micháliková, Barbara Tyukos Kaprinay, Boris Lipták, Karol Švík, Lukáš Slovák, Ružena Sotníková, Vladimír Knezl, Zdenka Gaspárová   +7 more
doaj   +1 more source

The Effectiveness of Nonsteroidal Anti-Inflammatory Drugs in Patients with Neurocompressive Pain Syndrome of Lumbosacral Spine in Degenerative Dystrophic Diseases

Bolʹ, Sustavy, Pozvonočnik, 2015
This article provides a retrospective analysis of medical records of 38 patients (28 women and 10 men) aged 54.7 ± 2.2 (27 to 86) years, who underwent conservative hospital treatment with a diagnosis of osteochondrosis, protrusion or herniated disc ...
Ya.V. Fischenko
doaj   +1 more source

Prenatal treatment prevents learning deficit in Down syndrome model. [PDF]

PLoS ONE, 2012
Down syndrome is the most common genetic cause of mental retardation. Active fragments of neurotrophic factors release by astrocyte under the stimulation of vasoactive intestinal peptide, NAPVSIPQ (NAP) and SALLRSIPA (SAL) respectively, have shown ...
Maddalena Incerti, Kari Horowitz, Robin Roberson, Daniel Abebe, Laura Toso, Madeline Caballero, Catherine Y Spong   +6 more
doaj   +1 more source

Clinical pilot study to evaluate the neovaginal PACIENA prosthesis® for vaginoplasty without skin grafts in women with vaginal agenesis

BMC Women's Health, 2019
Background To evaluate the feasibility and clinical outcomes of vaginoplasties using a neovaginal polylactic acid prosthesis made with 3-dimensional (3D) printing technology as an intraneovaginal mould.
Pedro Acién, Francisco J. Nohales-Alfonso, Maria-Luisa Sánchez-Ferrer, Miguel Sánchez-Lozano, Victoria Navarro-Lillo, Maribel Acién   +5 more
doaj   +1 more source

Cilostazol, a Phosphodiesterase 3 Inhibitor, Moderately Attenuates Behaviors Depending on Sex in the Ts65Dn Mouse Model of Down Syndrome

Frontiers in Aging Neuroscience, 2020
People with Down syndrome, which is a trisomy of chromosome 21, exhibit intellectual disability from infancy and neuropathology similar to Alzheimer’s disease, such as amyloid plaques, from an early age.
Masahiro Tsuji, Makiko Ohshima, Yumi Yamamoto, Satoshi Saito, Satoshi Saito, Yorito Hattori, Emi Tanaka, Akihiko Taguchi, Masafumi Ihara, Yuko Ogawa   +9 more
doaj   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations

Molecular Therapy: Nucleic Acids, 2021
Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only partial control of seizures and provide little benefit on the patient’s ...
Lucia Mora-Jimenez, Miguel Valencia, Rocio Sanchez-Carpintero, Jan Tønnesen, Saja Fadila, Moran Rubinstein, Manuela Gonzalez-Aparicio, Maria Bunuales, Eva Fernandez-Pierola, Maria Jesus Nicolas, Elena Puerta, Cristina Miguelez, Paula Gimenez Minguez, Sara Lumbreras, Gloria Gonzalez-Aseguinolaza, Ana Ricobaraza, Ruben Hernandez-Alcoceba   +16 more
doaj   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Attitudes toward uterus transplantation. An option for motherhood?

Acta Obstetricia et Gynecologica Scandinavica
Introduction Uterus transplantation is a novel surgical procedure that allows women with absolute uterine factor infertility to carry a pregnancy and give birth.
Mariona Rius, Marta Camacho, Nerea Tomás, Berta Díaz‐Feijoo, Camil Castelo‐Branco, Aina Borras, Jaume Tort, Francisco Carmona   +7 more
doaj   +1 more source

The Effect of SNAP Purchasing Power on Diet Quality

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The Supplemental Nutrition Assistance Program (SNAP) benefits millions of eligible low‐income Americans by increasing access to food, helping to reduce food insecurity. Previous studies have documented that the geographical variation in local food prices leads to significant differences in SNAP's purchasing power.
Farah Khan, Augustine Denteh
wiley   +1 more source