Results 111 to 120 of about 4,504,940 (369)

Stochastic mortality models: An infinite dimensional approach [PDF]

Finance and Stochastics 18(1):209-248, 2014, 2019
Demographic projections of future mortality rates involve a high level of uncertainty and require stochastic mortality models. The current paper investigates forward mortality models driven by a (possibly infinite dimensional) Wiener process and a compensated Poisson random measure.
arxiv  

Social Relationships and Mortality Risk: A Meta-analytic Review

PLoS Medicine, 2010
In a meta-analysis, Julianne Holt-Lunstad and colleagues find that individuals' social relationships have as much influence on mortality risk as other well-established risk factors for mortality, such as smoking.
Byu Scholarsarchive, J. Holt‐Lunstad, Timothy B. Smith, J. B. Layton   +3 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Child suicide rates during the COVID-19 pandemic in England

Journal of Affective Disorders Reports, 2021
Background: There is concern about the impact of COVID-19, and the control measures to prevent the spread, on children's mental health. The aim of this work was to identify if there had been a rise of childhood suicide during the COVID pandemic.
David Odd, Tom Williams, Louis Appleby, David Gunnell, Karen Luyt   +4 more
doaj  

Mortality decrease and mathematical limit of longevity [PDF]

arXiv, 2004
We wish to verify that the mortality deceleration (or decrease) is a consequence of the bending of the shape parameter at old ages. This investigation is based upon the Weon model (the Weibull model with an age-dependent shape parameter) for human survival and mortality curves.
arxiv  

Cancer incidence and mortality

Health at a Glance: Europe, 2019
A.G. Ramirez et al. (eds.), The South Texas Health Status Review: A Health Disparities Roadmap, DOI 10.1007/978-3-319-00233-0_5, © The Author(s) 2013 Cancer is a vital health issue in Texas.
Pamela K. Agovino, Stephanie Hill
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Overweight/obesity risks and prevalence of diabetes and hypertension in North Eastern India: An analysis using seemingly unrelated probit model

Clinical Epidemiology and Global Health, 2021
Objective: It would be reasonable to hypothesize that common unobserved factors, such as psychological stress and anxiety, as well as genetic and environmental factors, simultaneously influence the tendency for overweight or obesity and the prevalence of
Strong P. Marbaniang, Hemkhothang Lhungdim, Brijesh Yadav, Vinit Kumar Yajurvedi   +3 more
doaj  

The effect of cardiac resynchronization on morbidity and mortality in heart failure.

New England Journal of Medicine, 2005
BACKGROUND Cardiac resynchronization reduces symptoms and improves left ventricular function in many patients with heart failure due to left ventricular systolic dysfunction and cardiac dyssynchrony. We evaluated its effects on morbidity and mortality.
J. Cleland, J. Daubert, E. Erdmann, N. Freemantle, D. Gras, L. Kappenberger, L. Tavazzi   +6 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source