Results 121 to 130 of about 7,721,674 (406)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Environmental noise perception and risk of poor mental health in a region on the Mediterranean coast of Spain

Environmental Health and Preventive Medicine
Background: Exposure to environmental noise may have a negative impact on a population’s mental health. We estimated the prevalence of exposure perception to high environmental noise in the Valencian Community, a region on the Mediterranean coast of ...
Andreu Nolasco, Jesús Rabasco, Nayara Tamayo-Fonseca, Javier Casillas-Clot, Pamela Pereyra-Zamora   +4 more
doaj   +1 more source

Association of Cardiometabolic Multimorbidity With Mortality [PDF]

, 2015
Emanuele Di Angelantonio, Stephen Kaptoge, David Wormser, Peter Willeit, Adam S. Butterworth, Narinder Bansal, Linda M. O’Keeffe, Pei Gao, Angela Wood, Stephen Burgess, Daniel F. Freitag, Lisa Pennells, Sanne A. E. Peters, Carole Hart, Lise Lund Håheim, Richard F. Gillum, Børge G. Nordestgaard, Bruce M. Psaty, Bu B. Yeap, Matthew Knuiman, Paul J. Nietert, Jussi Kauhanen, Jukka T. Salonen, Lewis H. Kuller, Leon A. Simons, Yvonne T. van der Schouw, Elizabeth Barrett‐Connor, Randi Selmer, Carlos J. Crespo, Beatriz L. Rodríguez, W. M. Monique Verschuren, Veikko Salomaa, Kurt Svärdsudd, Pim van der Harst, Cecilia Björkelund, Lars Wilhelmsen, Robert B. Wallace, Hermann Brenner, Philippe Amouyel, Elizabeth Barr, Hiroyasu Iso, Altan Onat, Maurizio Trevisan, Ralph B. D’Agostino, Cyrus Cooper, Maryam Kavousi, Lennart Welin, Ronan Roussel, Frank B. Hu, Shinichi Sato, Karina W. Davidson, Barbara V. Howard, Maarten J.G. Leening, Annika Rosengren, Marcus Dörr, Dorly J. H. Deeg, Stefan Kiechl, Coen D.A. Stehouwer, Aulikki Nissinen, Simona Giampaoli, Chiara Donfrancesco, Daan Kromhout, Jackie F. Price, Annette Peters, Tom Meade, Edoardo Casiglia, Debbie A. Lawlor, John Gallacher, Dorothea Nagel, Oscar H. Franco, Gerd Assmann, Gilles R. Dagenais, J. Wouter Jukema, Johan Sundström, Mark Woodward, Eric J. Brunner, Kay-Tee Khaw, Nicholas J. Wareham, Eric A. Whitsel, Inger Njølstad, Bo Hedblad, Sylvia Wassertheil‐Smoller, Gunnar Engström, Wayne D. Rosamond, Elizabeth Selvin, Naveed Sattar, Simon G. Thompson, John Danesh   +87 more
openalex   +1 more source

Leveraging community mortality indicators to infer COVID-19 mortality and transmission dynamics in Damascus, Syria [PDF]

, 2021
Oliver J. Watson, Mervat Alhaffar, Zaki Mehchy, Charles Whittaker, Zack Akil, Nicholas F. Brazeau, Gina Cuomo-Dannenburg, Arran Hamlet, Hayley A Thompson, Marc Baguelin, Richard G. FitzJohn, Edward Knock, John A. Lees, Lilith K. Whittles, Thomas A. Mellan, Peter Winskill, Samir Bhatt, Bimandra A Djaafara, Christl A. Donnelly, Seth Flaxman, Katy A. M. Gaythorpe, Natsuko Imai, Elita Jauneikaite, Daniel J. Laydon, Swapnil Mishra, H. Juliette T. Unwin, Robert Verity, Natasha Howard, Hannah Clapham, Francesco Checchi, Neil M. Ferguson, Azra C. Ghani, Emma Beals, Patrick Walker   +33 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Alligator Diet in Relation to Alligator Mortality on Lake Griffin, FL [PDF]

, 2007
Alligator mississippiensis (American Alligators) demonstrated low hatchrate success and increased adult mortality on Lake Griffin, FL, between 1998 and 2003.
Carbonneau, Dwayne A., Percival, H. Franklin, Rice, Amanda Nicole, Ross, J. Perran, Woodward, Allan R.   +4 more
core  

Fluid balance and mortality in critically ill patients with acute kidney injury: a multicenter prospective epidemiological study [PDF]

, 2015
Na Wang, Li Jiang, Bo Zhu, Ying Wen, Xiuming Xi   +4 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Does happiness itself directly affect mortality? The prospective UK Million Women Study [PDF]

, 2015
Bette Liu, Sarah Floud, Kirstin Pirie, Jane Green, Richard Peto, Valerie Beral   +5 more
openalex   +1 more source