Results 261 to 270 of about 2,637,071 (274)

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance

Advanced Therapeutics, EarlyView.
Antimicrobial resistance necessitates the development of new antibiotics with “resistance‐breaking” properties. In this study, conjugation of polycationic peptides is proven to represent a versatile strategy for the fast and affordable reactivation of daptomycin.
Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein, Karel D. Klika, Christian Kleist, Julia Werner, Cornelius Domhan, Mara Bingel, Anna Müller, Marvin Rausch, Stefan Zimmermann, Knut Ohlsen, Uwe Haberkorn, Marcus Koch, Markus Bischoff, Tanja Schneider, Rolf Müller, Jennifer Herrmann, Walter Mier, Philipp Uhl   +21 more
wiley   +1 more source

Metabolic score for visceral fat is correlated with all-cause and cardiovascular mortality among individuals with non-alcoholic fatty liver disease. [PDF]

BMC Gastroenterol
Xie C, Chen X, Zhang J, Jiang X, Xu J, Lin H.   +5 more
europepmc   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

Global, regional and national trends in the epidemiology of rheumatoid arthritis from 1990 to 2021: an age-period-cohort effect analysis of the global burden of disease study 2021. [PDF]

RMD Open
Tang K, Zhu L, Shan S, Luo Z, Zhou J, Ying J, Wu J, Shen G, Song P.   +8 more
europepmc   +1 more source

A Convoy of Magnetic Millirobots Transports Endoscopic Instruments for Minimally‐Invasive Surgery

Advanced Science, EarlyView.
The first electrocautery procedure performed by a team of millirobots (TrainBots) is presented. Enhanced with optimized feet, millirobots form a convoy to facilitate the collaborative transportation of wires and catheters through biological lumens, e.g. bile ducts. It opens up the possibility of using a team of mini‐robots in future endoscopic surgery.
Moonkwang Jeong, Xiangzhou Tan, Felix Fischer, Tian Qiu   +3 more
wiley   +1 more source

The association between body roundness index and mortality in diabetes. [PDF]

BMC Cardiovasc Disord
Liu H, Ye H, Zhang X, Wen Y, Wang J, Yu M, Yang X, Ma C, Wu L, Zhao Y, Wang L.   +10 more
europepmc   +1 more source

Performance of Liquid Biopsy‐Based Multi‐Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE‐I)

Advanced Science, EarlyView.
Following a comparative analysis of omics‐based cancer detection models, a novel liquid biopsy‐based multi‐omics combined model is developed for the early detection of gynecological malignancies. By integrating cell‐free DNA methylation and tumor protein markers, the combined model demonstrates high specificity and sensitivity and is uniquely designed ...
Zheng Feng, Huijuan Ge, Jingshu Wang, Yanan Wang, Xiaoran Sun, Bo Yang, Siyu Cao, Chenlian Quan, Qinhao Guo, Yusheng Han, Feidie Duan, Fang liu, Jing Zhao, Guoqiang Wang, Yuzi Zhang, Shangli Cai, Xiaohua Wu, Hao Wen   +17 more
wiley   +1 more source

Impact of diabetes mellitus on 30-day mortality among acute stroke patients in northern Tanzania. [PDF]

PLoS One
Kamabu EM, Paluku JL, Howlett WP, Sadiq AM, Nziku EB, Eliah DT, Muhina IAI, Said FH, Mirai TE, Mkwizu EW, Lyamuya FS, Shao ER, Kilonzo KG, Maro VP, Urasa SJ, Chamba NG.   +15 more
europepmc   +1 more source

Association between alactic base excess on mortality in sepsis patients: a retrospective observational study. [PDF]

J Intensive Care
Liu J, Chen Y, Yang B, Zhao J, Tong Q, Yuan Y, Kang Y, Ren T.   +7 more
europepmc   +1 more source

Prostate Cancer Mortality in Iranian Men During 1990-2021: An Age-Period-Cohort and Joinpoint Regression Analysis. [PDF]

Prostate Cancer
Jafari F, Khodakarim S, Baberi F, Rezaianzadeh A.   +3 more
europepmc   +1 more source