Results 41 to 50 of about 2,729,591 (295)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The nexus between maternal antenatal care attendance, newborn postnatal care and neonatal mortality in India: a matched case-control study

BMC Pregnancy and Childbirth
Introduction Our study examines the relationship between newborn postnatal care and neonatal mortality stratified by maternal antenatal care attendance under a matched case-control framework.
Wahengbam Bigyananda Meitei, Abhishek Singh   +1 more
doaj   +1 more source

Socioeconomic inequalities in tobacco cessation among Indians above 15 years of age from 2009 to 2017: evidence from the Global Adult Tobacco Survey (GATS)

BMC Public Health, 2022
Background Tobacco is strongly associated with socioeconomic status (SES), however evidence on differences in tobacco cessation by socio-economic attributes remains fragmented, especially in developing countries.
Rufi Shaikh, Nandita Saikia
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Exploring the link between particulate matter pollution and acute respiratory infection risk in children using generalized estimating equations analysis: a robust statistical approach

Environmental Health
Background India is facing a burdensome public health challenge due to air pollution, with a particularly high burden of acute respiratory infections (ARI) among children. To address this issue, our study aims to evaluate the association between exposure
Mihir Adhikary, Piyasa Mal, Nandita Saikia   +2 more
doaj   +1 more source

Epidemiology of perioperative cardiac arrest and mortality in Brazil: a systematic review

Brazilian Journal of Anesthesiology, 2020
Background and objectives: The perioperative cardiac arrest (CA) and mortality rates in Brazil, a developing country, are higher than in developed countries.
Leandro Gobbo Braz, Arthur Caus de Morais, Rafael Sanchez, Daniela de Sá Menezes Porto, Mariana Pacchioni, Williany Dark Silva Serafim, Norma Sueli Pinheiro Módolo, Paulo do Nascimento, Jr, Mariana Gobbo Braz, José Reinaldo Cerqueira Braz   +9 more
doaj  

Smokeless tobacco, associated risk factors and women health: the study of garment workers in urban Mumbai, India

Tobacco Induced Diseases, 2018
Background India is one of the world's largest producers and consumers of tobacco. Smoking is rare among Indian women, but research shows that Indian women's use of smokeless tobacco products is increasing, with negative consequences on reproductive ...
Prashika Kurlikar
doaj   +1 more source

The effects of community clustering on under-five mortality in India: a parametric shared frailty modelling approach

Genus, 2022
The study of the effect of community clustering of under-five mortality has its implications in both research and policy. Studies have shown the contribution of community factors on under-five mortality.
Wahengbam Bigyananda Meitei, Abhishek Singh, Laishram Ladusingh   +2 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Empowering tribal women: a comparative analysis of matrilineal and patrilineal societies in India

Cogent Social Sciences
Tribal societies are often considered egalitarian, especially in contrast to the hierarchical caste society. However, tribal societies are not homogeneous, as both matrilineal and patrilineal tribes exist in India. This study examines whether matrilineal
Piyasa Mal, Nandita Saikia
doaj   +1 more source