Results 71 to 80 of about 3,266,788 (299)

Research note: Antiviral effect of remdesivir against experimental Newcastle disease virus infection in chickens

Poultry Science
Newcastle disease (ND), caused by the Newcastle disease virus (NDV), has no approved therapy, and vaccination often fails to eradicate infection in endemic areas.
Hiewa Othman Dyary
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Air pollutants and primary liver cancer mortality: a cohort study in crop-burning activities and forest fires area

Frontiers in Public Health
IntroductionNorthern Thailand experiences high levels of air pollution in the dry season due to agricultural waste burning and forest fires. Some air pollutants can enter the bloodstream, and the liver has the role of detoxifying these along with other ...
Natthapat Thongsak, Taned Chitapanarux, Anon Chotirosniramit, Somvilai Chakrabandhu, Patrinee Traisathit, Nawapon Nakharutai, Pimwarat Srikummoon, Salinee Thumronglaohapun, Titaporn Supasri, Phonpat Hemwan, Imjai Chitapanarux   +10 more
doaj   +1 more source

Hedging Pure Endowments with Mortality Derivatives [PDF]

, 2010
In recent years, a market for mortality derivatives began developing as a way to handle systematic mortality risk, which is inherent in life insurance and annuity contracts.
Wang, Ting, Young, Virginia R.
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The trends of mortality and years of life lost of cancers in urban and rural areas in China, 1990‐2017

Cancer Medicine, 2020
Background With the rapid development of the socioeconomic status, the mortality of several cancers has been changed in China during the past 30 years. We aimed to estimate the trends of mortality and years of life lost (YLLs) of various cancers in urban
Xingzu Cen, Dongming Wang, Weiwei Sun, Limin Cao, Zhuang Zhang, Bin Wang, Weihong Chen   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Trends of acute myocardial infarction-related deaths in US patients from 1999 to 2020

Archives of Medical Science: Atherosclerotic Diseases
Introduction The objective of this study was to analyze the temporal trends and demographic/geographical disparities in acute myocardial infarction (AMI)-related mortality among individuals aged 15 and older across the United Sates (US).
Irfan Ullah, Hanzala Ahmed Farooqi, Owais Ahmad, Muhammad Irfan, Ejaz Khan, Osama Ali Khan, Aman Goyal, Abdul Wali Khan, Zeeshan Sattar, Samay Mehta, Azeem Hassan, Hasan Ahmad, Qadeer Abdul, Muhammad Sohaib Aghar, Raheel Ahmed   +14 more
doaj   +1 more source

Using HIV-attributable mortality to assess the impact of antiretroviral therapy on adult mortality in rural Tanzania. [PDF]

, 2014
BACKGROUND: The Tanzanian national HIV care and treatment programme has provided free antiretroviral therapy (ART) to HIV-positive persons since 2004.
Alison Wringe, Basia Zaba, Chifundo Kanjala, Clara Calvert, Denna Michael, Emma Slaymaker, Floyd S, Jim Todd, Kirkwood BR, Mark Urassa, Raphael Isingo, World Health Organization   +11 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source