Results 161 to 170 of about 8,327 (235)

Young bodies, aging ovaries: A systematic review and meta‐synthesis of women's perspectives on spontaneous premature ovarian insufficiency

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives Spontaneous premature ovarian insufficiency (POI) is a condition characterized by the cessation of ovarian function before age 40, unrelated to medical interventions. It affects approximately 3.5% of women worldwide and can result in significant emotional, physical, and social consequences.
Maria Patricia Roman, Shaurya Aggarwal, Stergios K. Doumouchtsis   +2 more
wiley   +1 more source

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

iMetaMed, EarlyView.
A pan‐cancer atlas deciphers tumor‐induced reprogramming in bone metastases. Malignant evolution toward MYC/proliferation is a hallmark of bone metastases. Niche‐mediated immune dysfunction is characterized by immature pDCs, impaired antigen presentation and phagocytosis in TAMs, and exhausted T cells.
Yitong Pan, Zhou Yang, Junyuan Deng, Feng Liu, Guang Lei   +4 more
wiley   +1 more source

The gut microbiome organ

iMeta, EarlyView.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Self‐Esteem and Repetitive Negative Thinking as Mediators of the Association Between Bullying and Disordered Eating

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objective Eating disorders are associated with marked distress and impairment, including elevated risk for anxiety, depression, and suicidality. Bullying victimization is associated with eating disorder symptoms in late adolescence and young adulthood, when peer relationships and social evaluation are developmentally salient.
Kaitlynn E. Ellis, Camille Archer, Gabrielle E. Reimann, Yulan D. Chen, Ralph E. Francois, Antonia N. Kaczkurkin   +5 more
wiley   +1 more source

Optimizing Expectations Leads to Enhanced Efficacy of a Mindfulness‐Based Intervention in Individuals With Low‐Baseline Expectations: A Randomized Controlled Trial

Journal of Clinical Psychology, EarlyView.
ABSTRACT Introduction Treatment expectations for medical and psychological treatments and positive patient‐provider interactions are critical mechanisms driving the placebo effect and may augment an intervention's effects. However, it remains unclear whether optimizing treatment expectations is beneficial for all individuals.
Stefan Salzmann, Frank Euteneuer, Christiane A. Melzig, Winfried Rief, Christoph Benke   +4 more
wiley   +1 more source

Heat, Health and Holidays: Reported Heat Related Adjustments to Australian Tourist Behaviour

International Journal of Climatology, EarlyView.
This study assessed how climate‐related hazards affect Australian tourists' travel planning. While 80% of tourists report no impact, the 20% who do experience disruption most commonly change their activities, timing, or destination, with heat and rain affecting the same proportion of tourists across beach, city, nature, and family tourism types ...
Kerstin K. Zander, Sohail Ali, Amila Kasun Sampath Udage Kankanamge, Ronju Ahammad, Jonatan Lassa, Matthew Abunyewah, Michael Odei Erdiaw‐Kwasie, Stephen T. Garnett   +7 more
wiley   +1 more source

Durable Cancer Control and Extended Long‐Term Survival Following Salvage Surgery for Squamous Cell Carcinoma of the Anal Canal: A Cohort Study

Journal of Surgical Oncology, EarlyView.
ABSTRACT Aim Salvage surgery is the standard‐of‐care for patients with squamous cell carcinoma of the anal canal (SCCa) who experience isolated locoregional failure after upfront chemoradiotherapy. While perioperative morbidity and short‐term survival outcomes have been described, long‐term outcomes of surgical salvage are unknown.
Paul Savage, David P. Cyr, Dan E. Schiller, Bernard J. Cummings, Alexandra M. Easson, Andrew J. Smith, Carol J. Swallow   +6 more
wiley   +1 more source

Understanding and Addressing Delays in Endocrine Surgery: Insights From a Mixed‐Methods Study and a Pilot Educational Intervention

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Delays in endocrine surgical care contribute to adverse events, patient dissatisfaction, and mortality. Communication is an overlooked contributor. This study identified multi‐level drivers of delay and piloted a provider‐focused intervention. Methods We conducted an IRB‐approved mixed‐methods study.
Stella Kim, Maxwell Foote, Sophia Zhang, Audrey Twyford, Abigail Fox, Jennifer E. Rosen   +5 more
wiley   +1 more source