Results 121 to 130 of about 1,111,194 (270)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

GUT inspired $SO\left(5\right)\times U\left(1\right)\times SU\left(3\right)$ gauge-Higgs unification

Physical Review, 2019
An SO(5)×U(1)×SU(3) gauge-Higgs unification model inspired by SO(11) gauge-Higgs grand unification is constructed in the Randall-Sundrum warped space. The 4D Higgs boson is identified with the Aharonov-Bohm phase in the fifth dimension. Fermion multiplets are introduced in the bulk in the spinor, vector and singlet representations of SO(5) such that ...
Funatsu, Shuichiro, Hatanaka, Hisaki, Hosotani, Yutaka, Orikasa, Yuta, Yamatsu, Naoki   +4 more
openaire  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

First observation of ${\Lambda }_b^0\to {\Sigma }_c^{(*)++}{D}^{(*)-}{K}^{-}$ decays

Physical Review
The four decays, Λb0→Σc(*)++D(*)−K−, are observed for the first time using proton-proton collision data collected with the LHCb detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb−1. By considering the Λb0→Λc+D¯0K− decay as reference channel, the following branching fraction ratios are measured to be B(Λb0 ...
Aaij, R., Abdelmotteleb, A. S. W., Abellan Beteta, C., Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Aliouche, Z., Alvarez Cartelle, P., Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreola, P., Andreotti, M., Andreou, D., Anelli, A., Ao, D., Archilli, F., Argenton, M., Arguedas Cuendis, S., Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Audurier, B., Bacher, D., Bachiller Perea, I., Bachmann, S., Bachmayer, M., Back, J. J., Baladron Rodriguez, P., Balagura, V., Baldini, W., Baptista de Souza Leite, J., Barbetti, M., Barbosa, I. R., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Bartz, J., Baryshnikov, F., Basels, J. M., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Beiter, A., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Bernet Andres, S., Bertella, C., Bertolin, A., Betancourt, C., Betti, F., Bex, J., Bezshyiko, Ia., Bhom, J., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bocharnikov, V., Boelhauve, J. A., Boente Garcia, O., Boettcher, T., Bohare, A., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Brea Rodriguez, A., Breer, N., Brodzicka, J., Brossa Gonzalo, A., Brown, J., Brundu, D., Buchanan, E., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Bursche, A., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calefice, L., Cali, S., Calvi, M., Calvo Gomez, M., Cambon Bouzas, J. I., Campana, P., Campora Perez, D. H., Campoverde Quezada, A. F., Capelli, S., Capriotti, L., Caravaca-Mora, R., Carbone, A., Carcedo Salgado, L., Cardinale, R., Cardini, A., Carniti, P., Carus, L., Casais Vidal, A., Caspary, R., Casse, G., Castro Godinez, J., Cattaneo, M., Cavallero, G., Cavallini, V., Celani, S., Cerasoli, J., Cervenkov, D., Cesare, S., Chadwick, A. J., Chahrour, I., Charles, M., Charpentier, Ph., Chavez Barajas, C. A., Chefdeville, M., Chen, C., Chen, S., Chen, Z., Chernov, A., Chernyshenko, S., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Cid Vidal, X., Ciezarek, G., Cifra, P., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Cocha Toapaxi, C., Coco, V., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Congedo, L., Contu, A., Cooke, N., Corredoira, I., Correia, A.   +199 more
openaire  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Bosonic algebraic approach applied to the $\left[QQ\right]\left[\overline{Q}\overline{Q}\right]$ tetraquarks

Physical Review, 2022
The exact eigenenergies of the T4c=[cc][c¯c¯], T4b=[bb][b¯b¯], and T2[bc]=[bc][b¯c¯] tetraquarks are calculated within the extended transitional Hamiltonian approach, in which the so-called Bethe ansatz within an infinite-dimensional Lie algebra is used.
Majarshin, A. J., Luo, Yan-An, Pan, Feng, Segovia, J.   +3 more
openaire  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source