Results 151 to 160 of about 1,111,194 (270)

“Il fier tiranno” Divine Right and ragion di stato in Girolamo Graziani’s Il Cromuele

Mos Historicus
The execution of King Charles I in 1649 sparked outrage across Europe: after years of civil war, the anointed sovereign of England, Scotland, and Ireland was to die by parliamentary order.
Fabio Battista
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dark matter from $SU\left(6\right)\to SU\left(5\right)\times U(1{)}_N$

Physical Review, 2021
Matter and dark matter are unified under the framework of SU(6)→SU(5)×U(1)N. A dark-matter candidate is possible, not because it is stable, but because it has a very long lifetime, in analogy to that of the proton in theories of grand unification. A specific example is presented.
openaire  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Ultraviolet to infrared evolution and nonperturbative behavior of $\mathrm{SU}\left(N\right)\otimes \mathrm{SU}(N-4)\otimes U\left(1\right)$ chiral gauge theories

Physical Review, 2019
We analyze the ultraviolet to infrared evolution and nonperturbative properties of asymptotically free SU(N)⊗SU(N−4)⊗U(1) chiral gauge theories with Nf copies of chiral fermions transforming according to ([2]N,1)N−4+([1¯]N,[1¯]N−4)−(N−2)+(1,(2)N−4)N, where [k]N and (k)N denote the antisymmetric and symmetric rank−k tensor representations of SU(N) and ...
Ryttov, Thomas A., Shrock, Robert
openaire  

Evidence for a vector charmoniumlike state in $e^{+}{e}^{-}\to D_s^{+}{D}_{s2}^{*}(2573{)}^{-}+c.c.$

Physical Review, 2020
We report the measurement of e+e−→Ds+Ds2*(2573)−+c.c. via initial-state radiation using a data sample of an integrated luminosity of 921.9 fb−1 collected with the Belle detector at the ϒ(4S) and nearby. We find evidence for an enhancement with a 3.4σ significance in the invariant mass of Ds+Ds2*(2573)−+c.c.
Jia, S., Shen, C. P., Adachi, I., Aihara, H., Al Said, S., Asner, D. M., Atmacan, H., Aulchenko, V., Aushev, T., Ayad, R., Badhrees, I., Behera, P., Belous, K., Bennett, J., Besson, D., Bhardwaj, V., Bilka, T., Biswal, J., Bonvicini, G., Bozek, A., Bračko, M., Browder, T. E., Campajola, M., Červenkov, D., Chang, P., Chen, A., Cheon, B. G., Chilikin, K., Cho, K., Choi, S.K., Choi, Y., Choudhury, S., Cinabro, D., Cunliffe, S., Dash, N., De Nardo, G., Di Capua, F., Doležal, Z., Dong, T. V., Eidelman, S., Epifanov, D., Fast, J. E., Ferber, T., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Gabyshev, N., Garmash, A., Giri, A., Goldenzweig, P., Golob, B., Grzymkowska, O., Hartbrich, O., Hayasaka, K., Hayashii, H., Hou, W.S., Hsu, C.L., Inami, K., Inguglia, G., Ishikawa, A., Itoh, R., Iwasaki, M., Iwasaki, Y., Jeon, H. B., Jin, Y., Joo, K. K., Karyan, G., Kawasaki, T., Kiesling, C., Kim, B. H., Kim, D. Y., Kim, K.H., Kim, S. H., Kim, Y.K., Kinoshita, K., Kodyš, P., Korpar, S., Kotchetkov, D., Križan, P., Kroeger, R., Krokovny, P., Kulasiri, R., Kuzmin, A., Kwon, Y.J., Lalwani, K., Lange, J. S., Lee, S. C., Li, L. K., Li, Y. B., Li Gioi, L., Libby, J., Lieret, K., Liventsev, D., MacNaughton, J., MacQueen, C., Masuda, M., Matsuda, T., Matvienko, D., Merola, M., Mizuk, R., Moon, T. J., Mori, T., Mrvar, M., Nakao, M., Nayak, M., Nisar, N. K., Nishida, S., Ogawa, S., Ono, H., Oskin, P., Pakhlov, P., Pakhlova, G., Pardi, S., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Popov, V., Prencipe, E., Prim, M. T., Rostomyan, A., Rout, N., Russo, G., Sakai, Y., Sandilya, S., Santelj, L., Sanuki, T., Savinov, V., Schnell, G., Schueler, J., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shapkin, M., Shebalin, V., Shiu, J.G., Shwartz, B., Solovieva, E., Stanič, S., Starič, M., Stottler, Z. S., Strube, J. F., Sumihama, M., Sumiyoshi, T., Sutcliffe, W., Takizawa, M., Tanida, K., Tenchini, F., Uchida, M., Uglov, T., Unno, Y., Uno, S., Usov, Y., Van Tonder, R., Varner, G., Vinokurova, A., Wang, C. H., Wang, E., Wang, M.Z., Wang, P., Wang, X. L., Watanabe, M., Won, E., Xu, X., Yan, W., Yang, S. B., Ye, H., Yuan, C. Z., Yusa, Y., Zhang, Z. P., Zhilich, V., Zhukova, V., Zhulanov, V.   +176 more
openaire  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Production of $D^{(*)}{\overline{D}}^{(*)}$ near the thresholds in $e^{+}{e}^{-}$ annihilation

Physical Review
It is shown that the nontrivial energy dependencies of DD¯, DD¯*, and D*D¯* pair production cross sections in e+e− annihilation are well described within the approach based on an account of the final-state interaction of produced particles. This statement is valid for the production of charged and neutral particles.
Salnikov, S. G., Milstein, A. I.
openaire  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source