Results 261 to 270 of about 1,220,527 (364)

Detecting Hachimoji DNA: An Eight-Building-Block Genetic System with MoS2 and Janus MoSSe Monolayers

open access: green
Vasudeo Babar   +5 more
openalex   +2 more sources

SO(10)SU(5)×U(1)χ as the origin of dark matter

open access: yesPhysical Review, 2018
In the decomposition of SO(10) grand unification to SU(5)×U(1)χ, two desirable features are obtained with the addition of one colored fermion octet Ω, one electroweak fermion triplet Σ and one complex scalar triplet S to the particle content of the standard model with two Higgs doublets. They are (1) gauge coupling unification of SU(3)C×SU(2)L×U(1)Y to
openaire  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Expanding Horizons in Cholangiocarcinoma: Emerging Targets Beyond FGFR2 and IDH1. [PDF]

open access: yesInt J Mol Sci
Darman L   +4 more
europepmc   +1 more source

Ni‐ and Co‐Substituted Metallic MoS2 for the Alkaline Hydrogen Evolution Reaction

open access: green, 2020
Nuwan H. Attanayake   +6 more
openalex   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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