Results 101 to 110 of about 943,002 (392)

A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing

Genome Medicine, 2019
Although mosaic variation has been known to cause disease for decades, high-throughput sequencing technologies with the analytical sensitivity to consistently detect variants at reduced allelic fractions have only recently emerged as routine clinical ...
Ye Cao, M. Tokita, Ed S. Chen, R. Ghosh, Tiansheng Chen, Yanming Feng, Elizabeth B. Gorman, Federica Gibellini, P. Ward, Alicia A. Braxton, Xia Wang, Linyan Meng, Rui Xiao, W. Bi, F. Xia, C. Eng, Yaping Yang, T. Gambin, C. Shaw, Pengfei Liu, P. Stankiewicz   +20 more
semanticscholar   +1 more source

BioCNTs Mediated Delivery of Systemically Mobile Small RNAs via Leaf Spray to Control Both Tomato DNA and RNA Viruses

Advanced Science, EarlyView.
A carbon nanotube‐based biopesticide system (BioCNTs) enables efficient delivery and systemic movement of RNAi molecules to control major tomato viruses. By integrating shRNA and tRNA‐like structures (TLS) with BioCNTs, this green and scalable approach achieves long‐term silencing and high antiviral efficacy through simple foliar spraying.
Xuedong Liu, Xiaofei Liang, Zipeng Cai, Zheng Liu, Xuefeng Wang, Changyong Zhou, Mengji Cao, Sijia Liu   +7 more
wiley   +1 more source

Solid state television camera system Patent [PDF]

, 1969
Solid state television camera system consisting of monolithic semiconductor mosaic sensor and molecular digital readout ...
Broderick, J. C., Callahan, D. E., Huggins, C. T., List, W. F., Schuster, M. A., Strull, G.   +5 more
core   +1 more source

Mosaic Turner syndrome shows reduced penetrance in an adult population study

Genetics in Medicine, 2018
Many women with X chromosome aneuploidy undergo lifetime clinical monitoring for possible complications. However, ascertainment of cases in the clinic may mean that the penetrance has been overestimated.
M. Tuke, K. Ruth, A. Wood, R. Beaumont, J. Tyrrell, Samuel E. Jones, H. Yaghootkar, C. Turner, M. Donohoe, A. Brooke, M. Collinson, R. Freathy, M. Weedon, T. Frayling, A. Murray   +14 more
semanticscholar   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

Scientific Reports, 2017
CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome.
Zhuchi Tu, Weili Yang, Sen Yan, An Yin, Jinquan Gao, Xudong Liu, Yinghui Zheng, J. Zheng, Zhujun Li, Su Yang, Shihua Li, Xiangyu Guo, Xiao-Jiang Li   +12 more
semanticscholar   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Characterisation and detection of dasheen mosaic potyvirus in Zantedeschia : a thesis presented in partial fulfilment of the requirements for the degree of Master of Horticultural Science in Plant Health at Massey University, Palmerston North, New Zealand [PDF]

, 1995
Four potyvirus isolates believed to be dasheen mosaic potyvirus, the most frequently occurring virus to infect members of the Araceae, were obtained from Caladium, Colocasia, Xanthosoma and Zantedeschia in world-wide locations.
Matthews, Christine Grace
core  

An evidence-based scoring system for prioritizing mosaic aneuploid embryos following preimplantation genetic screening.

Reproductive Biomedicine Online, 2018
The aim of this study was to devise an evidence-based scoring system for prioritizing mosaic aneuploid embryos for transfer. A retrospective analysis was performed of all sequential cytogenetic and molecular results on chorionic villi samples (n = 72,472)
F. Grati, G. Gallazzi, Lara Branca, F. Maggi, G. Simoni, Y. Yaron   +5 more
semanticscholar   +1 more source