Results 101 to 110 of about 2,895,342 (271)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

High Upper Critical Field and Type II Superconductivity in Epitaxial Cubic W2N Thin Films

Advanced Science, EarlyView.
Superconducting thin films of stoichiometric W2N demonstrate a high upper critical field (Hc2) of ∼ 8.5 T, uncommon among binary transition metal nitrides. This robust superconducting response under high magnetic fields highlights the technological relevance of W2N for superconducting applications, e.g., integrated quantum and cryogenic electronics ...
Aditya Singh, Arnaud le Febvrier, Sanath Kumar Honnali, Abhisek Mishra, Grzegorz Greczynski, Subhankar Bedanta, Per Eklund, Ajay Soni   +7 more
wiley   +1 more source

Commentary: Mosaic and Concerted Brain Evolution: The Contribution of Microscopic Comparative Neuroanatomy in Lower Vertebrates

Frontiers in Neuroanatomy, 2020
Romain Willemet
doaj   +1 more source

Implementation and sustainability of mentorship for public health student success

Frontiers in Public Health
Historically underrepresented and marginalized (URM) graduate students in public health, including students of color, first-generation, and international students, often face structural inequities such as limited representation among faculty ...
Stephanie A. Grilo, Michael A. Joseph, Goleen Samari, Goleen Samari   +3 more
doaj   +1 more source

Mosaic evolution of clathrin-mediated endocytosis in fungi

Current Biology
Clathrin-mediated endocytosis is an ancient eukaryotic trafficking pathway, which transports plasma membrane and associated cargo into the cell and is involved in numerous cell- and tissue-level processes. Cargo selection and clathrin-coated vesicle formation are mediated by over 60 proteins that assemble in a regular and sequential manner at the ...
Andrea Picco, Christopher P. Toret, Anne-Sophie Rivier-Cordey, Marko Kaksonen   +3 more
openaire   +2 more sources

Genetic characterization of Pepino mosaic virus isolates from Belgian greenhouse tomatoes reveals genetic recombination [PDF]

, 2008
Over a period of a few years, Pepino mosaic virus (PepMV) has become one of the most important viral diseases in tomato production worldwide. Infection by PepMV can cause a broad range of symptoms on tomato plants, often leading to significant financial ...
Wittemans, Lieve, Paeleman, A., Thomma, B.P.H.J., Paeleman, Anneleen, Vanachter, Alfons C. R. C., Goen, K., Hanssen, Inge M., Lievens, Bart, Hanssen, I.M., Bragard, C., Wittemans, L.P.F., Vanachter, A.C.R.C., Vanachter, Alfons C.R.C., Thomma, Bart P.H.J., Bragard, Claude, Groen, Kris, Goen, Kris, Thomma, Bart P. H. J., Lievens, B.   +18 more
core   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

The role of seed transmission in the spread of cereal viruses: Global challenges and prevalent threats in Ukraine

Plant Protection Science
The transmission of plant viruses through seed plays a fundamental role in virus spread, persistence, and survival, particularly in economically important crops.
Halyna Snihur, Tetiana Shevchenko, Oleksiy Shevchenko, Anhelina Kyrychenko   +3 more
doaj   +1 more source

Fertile Goeppertella from the Jurassic of Patagonia: mosaic evolution in the Dipteridaceae-Matoniaceae lineage. [PDF]

AoB Plants, 2023
Yañez A, Escapa IH, Choo TYS.
europepmc   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source