Results 41 to 50 of about 225,828 (274)

Becoming a mother: a study exploring occupational change in first-time motherhood [PDF]

open access: yes, 2005
Having a first baby is considered a major life event, due to significant role change impacting on the ordinary and familiar activities the new mother performs every day. The aim of this study was to explore changes in the occupational lives of first time
Corr, Susan, Earle, Sarah, Horne, Jane
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Talking About Motherhood Matters: Articulation of Population Policies through National Day Rally Speeches in Singapore [PDF]

open access: yes, 2012
Women’s reproductive rights have always been a site of contestation. The central question this paper seeks to answer is how motherhood is constructed through the repetition of population policies by government officials and how this articulation becomes ...
Tan, Jasmine E.
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Endothelial function in children with idiopathic uveitis and uveitis associated with juvenile idiopathic arthritis

open access: yesJournal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Uveitis – inflammation of the choroid of the eye – is one of the severe comorbid conditions in rheumatic diseases, mainly juvenile idiopathic arthritis, often asymptomatic, untimely diagnosed, and progressive with the risk of vision loss ...
O.A. Oshlianska   +3 more
doaj   +1 more source

Political motherhood and the everyday experience of mothering : a comparison of the child care strategies of French and British working mothers [PDF]

open access: yes, 1999
In contrast to the majority of research on the relationship between women and the state which bases its findings on nationally aggregated data and concentrates its analysis on the forces which shape national policy concerning gender, this article adopts ...
Windebank, J.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

First-Birth Timing and the Motherhood Wage Gap in 140 Occupations

open access: yesSocius, 2020
Is delayed fertility associated with a reduced motherhood wage gap in all occupations? Using multilevel models and data from the 2011–2015 American Community Survey, O*NET, and the Current Population Survey, I examine whether delayed fertility is ...
Liana Christin Landivar
doaj   +1 more source

From motherhood to maternal subjectivity [PDF]

open access: yes, 2001
In this paper I try to work out what would be involved - and what would be some of the implications - in moving from the idea of motherhood to maternal subjectivity (which I theorise through the lens of unconscious intersubjectivity). Motherhood connotes
Hollway, Wendy
core  

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