Results 41 to 50 of about 244,158 (323)

Talking About Motherhood Matters: Articulation of Population Policies through National Day Rally Speeches in Singapore [PDF]

open access: yes, 2012
Women’s reproductive rights have always been a site of contestation. The central question this paper seeks to answer is how motherhood is constructed through the repetition of population policies by government officials and how this articulation becomes ...
Tan, Jasmine E.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Becoming a mother: a study exploring occupational change in first-time motherhood [PDF]

open access: yes, 2005
Having a first baby is considered a major life event, due to significant role change impacting on the ordinary and familiar activities the new mother performs every day. The aim of this study was to explore changes in the occupational lives of first time
Corr, Susan, Earle, Sarah, Horne, Jane
core  

"Mothers as Candy Wrappers": Critical Infrastructure Supporting the Transition into Motherhood [PDF]

open access: yes, 2019
Copyright © ACM. The transition into motherhood is a complicated and often unsupported major life disruption. To alleviate mental health issues and to support identity re-negotiation, mothers are increasingly turning to online mothers\u27 groups ...
Barkhuus, Louise   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Endothelial function in children with idiopathic uveitis and uveitis associated with juvenile idiopathic arthritis

open access: yesJournal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Uveitis – inflammation of the choroid of the eye – is one of the severe comorbid conditions in rheumatic diseases, mainly juvenile idiopathic arthritis, often asymptomatic, untimely diagnosed, and progressive with the risk of vision loss ...
O.A. Oshlianska   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Closing/Closed Gastroschisis (CGS): Antenatal Predictors and Surgical Strategies in Cases of Unique Anatomy from a Case Series

open access: yesChildren
Background: Closing/closed gastroschisis (CGS) accounts for approximately 6% of gastroschisis cases globally. Currently, no consensus exists regarding: antenatal predictors of CGS types, optimal antenatal management (ultrasound screening frequency ...
Dmitrii Morozov   +8 more
doaj   +1 more source

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