Results 41 to 50 of about 64,662 (306)

Primary ovarian leiomyoma in a patient with uterine leiomyoma

Медицинский вестник Юга России
A small, unilateral tumor. Most ovarian leiomyomas (OLM) are benign, but can range from benign to borderline with malignant degeneration. In many patients, OLM are asymptomatic and are detected accidentally during surgery.
V. B. Tskhay, E. K. Grebennikova, I. S. Brekhova, N. M. Yametova, E. Sh. Dzhunagova   +4 more
doaj   +1 more source

Teenage pregnancy and motherhood: How might evolutionary theory inform policy? [PDF]

, 2011
Teenage pregnancy and motherhood are considered to be pressing social concerns and, in the majority of developed countries, are often viewed as problems in need of solutions.
Clegg, Helen, Sarah E. Johns, Dickins, Thomas E, Clegg, Helen T., Helen T. Clegg, Johns, Sarah E, Thomas E. Dickins, Johns, Sarah E., Dickins, Thomas E.   +8 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Personalized management strategies for patients with perimenopausal disorders under war-related stress

Репродуктивная эндокринология
Objective of the study: to investigate the frequency of menopausal transition symptoms in women aged 40–52 years under chronic stress due to the war in Ukraine. Materials and methods.
T.F. Tatarchuk, L.V. Kalugina, K.D. Plaksiieva, T.M. Tutchenko, T.I. Yusko   +4 more
doaj   +1 more source

Myths of motherhood. The role of culture in the development of postpartum depression

Annali dell'Istituto Superiore di Sanità, 2012
OBJECTIVES: This paper intends to offer a theoretical insight into the myths of motherhood and how these myths can bear on the pathogenesis of postpartum depression.
Alessandra Ambrosini, Giovanni Stanghellini   +1 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Anatomical urethral meatus dimensions in distal hypospadias and their impact on postoperative outcome

Вестник урологии
Introduction. The most widely used operative technique for distal hypospadias is tubularized incised plate (TIP) urethroplasty. Despite its relative technical simplicity and favourable outcomes, TIP may be complicated by scarring of the distal urethra ...
S. S. Zadykyan, R. S. Zadykyan, V. V. Sizonov, I. M. Kagantsov   +3 more
doaj   +1 more source

Implementation project of the non-pneumatic anti-shock garment and m-communication to enhance maternal health care in rural Tanzania

Reproductive Health, 2018
Background Obstetric hemorrhage (OH) remains one of the leading causes of maternal mortality, particularly in rural Africa. Tanzania has a high maternal mortality ratio, and approximately 80% of the population accesses health care lower level facilities,
Godfrey Mbaruku, Michelle Skaer Therrien, Robert Tillya, Selemani Mbuyita, Zacharia Mtema, Iddajovana Kinyonge, Ritha Godfrey, Silas Temu, Suellen Miller   +8 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source