Results 81 to 90 of about 89,906 (291)

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li   +15 more
wiley   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

open access: yesAdvanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang   +4 more
wiley   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

open access: yesAdvanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu   +11 more
wiley   +1 more source

Gastrointestinal manifestations of COVID-19 in women with endometriosis: a prospective observational cohort study

open access: yesGastroenterologìa
Background. Women with endometriosis may be at increased risk of long COVID-19; however, clinical data on the persistence of gastrointestinal symptoms after COVID-19 in this group are limited, complicating post-infection management and follow-up planning.
Vol.V. Podolskyi   +3 more
doaj   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

open access: yesAdvanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li   +7 more
wiley   +1 more source

Motherhood Studies and Feminist Theory: Elisions and Intersections [PDF]

open access: yes, 2018
The study of motherhood has had an uneasy and ambivalent relationship to feminism and feminist theory. Ranging from radical feminist rejection of motherhood on the perceived basis of its inherent oppression of women, and the view that “motherhood has ...
Takševa, Tatjana
core   +1 more source

Conceptualising Non-Motherhood

open access: yes
This chapter introduces the volume by theorising non-motherhood, outlining existing scholarship on the topic, and presenting the chapters in the volume.
Björklund, Jenny   +2 more
core   +1 more source

Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform Toward Non‐Invasive Diagnostics

open access: yesAdvanced Science, EarlyView.
Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform toward Non‐Invasive Diagnostics is a nature‐inspired strategy that engineers controlled randomness within block copolymer lamellae to achieve optical isotropy without compromising nanoscale periodicity.
Jin Man Kim   +6 more
wiley   +1 more source

Interrogating Motherhood

open access: yes
Cover -- Title -- Copyright -- Contents -- Acknowledgements -- 1 The Study of Motherhood -- 2 Reflections on Motherhood: Theory and Popular Culture -- 3 Paid Employment and the Practice of Motherhood -- 4 Enabling Policies: In Theory and in Practice -- 5
Ross, Lynda R.
core  

New Evidence on the Motherhood Wage Gap [PDF]

open access: yes
Using data from the 1979 National Longitudinal Survey of Youth, we assess the role of employment-based health insurance offers in explaining the motherhood wage gap.
Kimmel, Jean, Amuedo-Dorantes, Catalina
core  

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