Results 121 to 130 of about 3,421,417 (362)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Motion sickness, stress and the endocannabinoid system [PDF]

, 2010
A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting (N&V) during road, air or sea travel.
Kreth Simone, Feuerecker, Matthias, Matthias Feuerecker, Ines Kaufmann, Kaufmann, Ines, Kreth, Simone, Thieme, Detlef, Thieme Detlef, Choukèr Alexander, Schelling Gustav, Feuerecker Matthias, Michael Vogeser, Kaufmann Ines, Vogeser Michael, Manfred Thiel, Schelling, Gustav, Vogeser, Michael, Choukèr, Alexander, Detlef Thieme, Thiel, Manfred, Gustav Schelling, Alexander Choukèr, Daniela Hauer, Thiel Manfred, Hauer, Daniela, Simone Kreth, Hauer Daniela   +26 more
core   +1 more source

Synchronised Video, Motion Capture and Force Plate Dataset for Validating Markerless Human Movement Analysis

Scientific Data
The BioCV dataset is a unique combination of synchronised multi-camera video, marker based optical motion capture, and force plate data, observing 15 healthy participants (7 males, 8 females) performing controlled and repeated motions (walking, running ...
Murray Evans, Laurie Needham, Logan Wade, Martin Parsons, Steffi Colyer, Polly McGuigan, James Bilzon, Darren Cosker   +7 more
doaj   +1 more source

Do athletes alter their running mechanics after an Achilles tendon rupture?

Journal of Foot and Ankle Research, 2017
Background Over the past thirty years, there has been dramatic increase in incidence of Achilles tendon rupture in the athletic population. The purpose of this study was to compare the lower extremity mechanics of Achilles tendon ruptured runners with ...
Daniel Jandacka, Julia Freedman Silvernail, Jaroslav Uchytil, David Zahradnik, Roman Farana, Joseph Hamill   +5 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Beta oscillations predict the envelope sharpness in a rhythmic beat sequence

Scientific Reports
Periodic sensory inputs entrain oscillatory brain activity, reflecting a neural mechanism that might be fundamental to temporal prediction and perception.
Sabine Leske, Tor Endestad, Vegard Volehaugen, Maja D. Foldal, Alejandro O. Blenkmann, Anne-Kristin Solbakk, Anne Danielsen   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Visually guided reaching depends on motion area MT

, 2007
Visual information is crucial for goal-directed reaching. A number of studies have recently shown that motion in particular is an important source of information for the visuornotor system.
Goodale, M., Melvyn Goodale, David Whitney, Whitney, D., Rice, NJ, Walsh, Vincent, Rice, N.J., Milner, D, Ellison, Amanda, Goodale, Melvyn, Arnold, D, Ellison, A, Ellison, A., Goodale, M, Walsh, V., Milner, A.D., Whitney, D, David Milner, Vincent Walsh, A Ellison, Rice, Nichola J., Nichola J. Rice, Arnold, Derek, Whitney, David, Walsh, V, Milner, David, Arnold, D.   +26 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Respiratory-induced organ motion compensation for MRgHIFU [PDF]

, 2012
Summary: High Intensity Focused Ultrasound is an emerging non-invasive technology for the precise thermal ablation of pathological tissue deep within the body.
Arnold, Patrik
core   +1 more source