Results 51 to 60 of about 167,895 (261)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Novel Self-Adaptive Wind Speed Prediction Model Considering Atmospheric Motion and Fractal Feature
IEEE Access, 2020 Many of the previous investigations predicted wind speed by directly using wind speed data, which rarely considered physical characteristics of wind speed and was difficult to improve prediction accuracy further.
Ji Jin +4 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
A Method to Simulate the Heave-Pitch Coupled Motion of Spar Platforms
IEEE AccessThe purpose of this work is to explore the internal resonance exhibited by the heave-pitch coupled motion of a classic Spar platform via an equivalent analog circuit method.
Zhenhua Zhang, Chuyi Wang, Min Li
doaj +1 more source
Equations of Motion and Navier–Stokes Equations
ComputationIn this research, we present the analogies between variational calculations in cosmology and in classical mechanics. Our approach is based on the invariants for transformations of affine connections defined on N-dimensional manifolds (special cases are the 8-dimensional, 5-dimensional, and 4-dimensional manifolds used in cosmology and 2-dimensional ...
Dusan J. Simjanovic +4 more
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Mechanical Engineering Journal, 2020 This paper describes the theoretical modal analysis of continuous systems that are subjected to displacement excitation. Because vibration modes of continuous systems whose boundaries actively move are unknown, we proposed an equivalent replacement ...
Keisuke YAMADA, Hideo UTSUNO
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source