Results 41 to 50 of about 27,302 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ionic fluxes of charged particles at cathode region

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2007
We analyze the disperse particles charging at cathode region by collisional and diffusive mechanisms. The dependence of charge quantity at nanoparticles on their sizes and characteristics of motion in the electrical field is defined.
V. B. Oparin , M. V. Sosnina , K. N. Vinogradov   +2 more
doaj   +1 more source

Impact of the mass and other parameters of charged particles on the results of laser resonance acceleration [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2014
Theoretical and numerical analyses are presented concerning the conditions at whichthe charged particles of different masses can be accelerated to significant kinetic energy in the circularlypolarized laser or maser beams and a static magnetic field. The
Adam Dubik, Michał J. Małachowski
doaj   +1 more source

Charged particle motion in a highly ionized plasma [PDF]

Physics Reports, 2005
A recently introduced method utilizing dimensional continuation is employed to compute the energy loss rate for a non-relativistic particle moving through a highly ionized plasma. No restriction is made on the charge, mass, or speed of this particle.
Brown, Lowell S., Preston, Dean L., Singleton Jr, Robert L.   +2 more
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Ion motion in the current sheet with sheared magnetic field – Part 2: Non-adiabatic effects [PDF]

Nonlinear Processes in Geophysics, 2013
We investigate dynamics of charged particles in current sheets with the sheared magnetic field. In our previouspaper (Artemyev et al., 2013) we studied the particle motion in such magnetic field configurations on the basis of the quasi-adiabatic theory ...
A. V. Artemyev, A. I. Neishtadt, L. M. Zelenyi   +2 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Spinless Particles in Exponentially Varying Electric and Magnetic Fields

Advances in High Energy Physics, 2014
We investigate the motion of the charged spin-0 particles subjected to the space-dependent electric and magnetic fields. By selecting the external fields oriented parallel and orthogonal to each other, exact solutions of the motion are obtained for the ...
Kenan Sogut, Ali Havare
doaj   +1 more source

A correlational study: Establishing the link between quantum parameters and particle dynamics around Schwarzschild black hole

Results in Physics, 2021
The field of point particle dynamics is correlated with the study of particle dynamics around the black hole and one can initiate the study of a more complex motion of extended/celestial bodies.
Muhammad Saeed, Israr Ali Khan, Amir Sultan Khan, Shah Qasim Jan, Saeed Islam, Saleh S. Alarfaji, Aijaz Rasool Chaudhry   +6 more
doaj   +1 more source

Planar Solid‐State Nanopores Toward Scalable Nanofluidic Integration Based on CMOS Technology

Advanced Engineering Materials, EarlyView.
We present a scalable silicon‐based fabrication strategy for planar solid‐state nanopores to enable their integration with complex nanofluidic systems. Prototype devices demonstrate normal voltage‐current characteristics, good noise performance, and appreciable streaming currents. Our CMOS‐compatible fabrication process offers precise geometric control
Ngan Hoang Pham, Chenyu Wen, Mohammad Hadi Khaksaran, Won‐Yong Lee, Javier Cruz, Klas Hjort, Dongping Wu, Shi‐Li Zhang   +7 more
wiley   +1 more source