Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Stronger Activation of the Right Primary Motor Cortex in the Early Processing Stage of Negative Emotional Scenes Stimulation. [PDF]
Meng H, Zhang X, Zhang J, Zheng C.
europepmc +1 more source
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
Management of a Rare Combined Osseoligamentous Knee Injury: Tibial Plateau Fracture with High-Grade Posterior Cruciate Ligament Tear Treated by Arthroscopic Reconstruction and Osteosynthesis - A Case Report. [PDF]
Vivekkumar M +5 more
europepmc +1 more source
Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli +5 more
wiley +1 more source
Quo Vadis, Cinema Europaeum? Reflections on European Cinema in Digital Times
Daniel Biltereyst +2 more
doaj +1 more source
Teen Witches, Wiccans, and 'Wanna-Blessed-Be's': Pop-Culture Magic in Buffy the Vampire Slayer [PDF]
J. Lawton Winslade
doaj
Linguistic Validation and Cross-Cultural Adaptation of the Shoulder Telehealth Assessment Tool for Filipino Patients with Musculoskeletal Shoulder Condition: Cross-Sectional Study. [PDF]
Arboleda J +3 more
europepmc +1 more source
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht +53 more
wiley +1 more source

