Results 31 to 40 of about 1,398,686 (250)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
« On … on peut se reposer maintenant ? » :Foucault et les multiples subjectivités discursives de Spike [PDF]
Slayage, 2023 This article explores Spike’s development via a Foucauldian perspective of power and discourse. Discursive power resides in networks of relationships which allow “subjects [to] freely call upon differing discourses … and therefore, play games of identity”
Herrmann, Andrew F. +1 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Minor Gestures: Chantal Akerman’s Un jour Pina a demandé…
Cinéma & Cie, 2020 Drawing on Erin Manning’s concept of the ‘minor gesture’, this article engages with the choreographic and filmic value of gestural hands. It considers Bausch’s choreography as a gestural practice that intervenes into everyday comportment and habits to ...
Lucia Ruprecht
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Variety within Bigotry: From Individual to Systemic Monsterism in Buffy the Vampire Slayer [PDF]
Slayage, 2023 Scholars debate and categorize varieties of bigotry in terms of responsibility, whether individual, institutional, structural, systematic, or systemic. Using the distance of fantasy narrative and “monsterism” in specific cases in Buffy the Vampire Slayer,
Rocha, James, Rocha, Mona
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Cinéma & Cie, 2020 This article reads together the work of Yvonne Rainer and Carolee Schneemann, as situated between film, performance, as well as dance and painting, considering what their work reveals about a specific intermedial feminist aesthetics developing at this ...
Marta
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