Results 41 to 50 of about 582,776 (293)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Physics in Riemann's mathematical papers

, 2017
Riemann's mathematical papers contain many ideas that arise from physics, and some of them are motivated by problems from physics. In fact, it is not easy to separate Riemann's ideas in mathematics from those in physics.
A-M Legendre, AM Polyakov, AM Polyakov, B Riemann, B Riemann, B Riemann, B Riemann, B Riemann, C Reid, CF Gauss, CF Gauss, E Scholz, G Roch, GD Garland, GL Dirichlet, H Helmholtz von, H Weyl, I Kant, J Fourier, J. Dieudonné, History of algebraic geometry: An Outline of the History and Development of Algebraic Geometry, English translation by J. Sally, Wadsworth, Monterey, CA, JC Maxwell, JD Zund, JF Herbart, LV Ahlfors, MF Atiyah, P Dugac, P Stäckel, R Calinger, R Dedekind, R Farwell, R Narasimhan, RC Penner, SD Poisson, V-A Puiseux, V-A Puiseux, WH Meeks III   +35 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Colloquium : disclination loops, point defects, and all that in nematic liquid crystals [PDF]

, 2012
The homotopy theory of topological defects is a powerful tool for organizing and unifying many ideas across a broad range of physical systems. Recently, experimental progress was made in controlling and measuring colloidal inclusions in liquid ...
Abrikosov, A. A., Abrikosov, A. A., Bryan Gin-ge Chen, Chaikin, P. M., Coleman, S., Elisabetta A. Matsumoto, Gareth P. Alexander, Hatcher, A., Polyakov, A. M., Polyakov, A. M., Randall D. Kamien   +10 more
core   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Oneness With the Source as a Means of Reducing Motivated Reasoning About Climate Policy

International Journal of Communication
Addressing climate change requires persuading political conservatives—many of whom remain skeptical of climate science—to support climate initiatives.
Christopher J. Carpenter, Shannon M. Cruz   +1 more
doaj   +1 more source

Compilability of Abduction

, 2002
Abduction is one of the most important forms of reasoning; it has been successfully applied to several practical problems such as diagnosis. In this paper we investigate whether the computational complexity of abduction can be reduced by an appropriate ...
Bylander T., Cadoli M., Cialdea Mayer M., Darwiche A., Del Val A., Del Val A., Eiter T., Eiter T., Flach P., Johnson D. S., Levesque H. J., Marco Schaerf, Paolo Liberatore, Reiter R., Selman B.   +14 more
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

From Selective Exposure to Selective Information Processing: A Motivated Reasoning Approach

Media and Communication, 2019
Literature suggests that while without doubt people engage in selective exposure to information, this does not entail that they also engage in selective avoidance of opinion-challenging information. However, cross-cutting exposure does not always lead to
Lindita Camaj
doaj   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source