Advanced Science, EarlyView.Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance +17 more
wiley +1 more source
Learner agency in a problem-based learning curriculum: A qualitative study on perspectives of undergraduate dental students. [PDF]
PLoS OneGupta N, Sunil S, Ali K, Fink T, Du X.
europepmc +1 more source
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, EarlyView.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Intervention for minimizing the risk of drop-out in music school pupils-an exploratory study. [PDF]
Front PsycholKavčič Pucihar A +3 more
europepmc +1 more source
THE INFLUENCE OF STEM EDUCATION ON MOTIVATION TO LEARN IN MATHEMATICS LESSONS
Nazym Nurumova, Gulzhan Kudiretbai
openalex +2 more sources
Advanced Science, EarlyView.Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang +7 more
wiley +1 more source
Parents' roles in young learners' motivation and task engagement in Indonesian primary schools: Questionnaire development and validation. [PDF]
F1000ResLena MS, Nikolov M.
europepmc +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Evaluation of virtual reality versus plastinated specimens in musculoskeletal anatomy education for second year medical students. [PDF]
Sci Repde Melo EA +9 more
europepmc +1 more source