Results 121 to 130 of about 202,895 (276)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

Need-achievement, expectations and life purpose: A french-argentine study of PhDs in education [PDF]

open access: yes, 2017
Here we present a comparative research study of doctoral programs in the social sciences in Argentina and France (2009-2017). The focus is to analyze professional pathways and their relationship to base, socio-cultural, psychosocial and structural ...
Aparicio, Miriam Teresita
core  

Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis

open access: yesAdvanced Science, EarlyView.
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu   +4 more
wiley   +1 more source

The hippocampus and cerebellum in adaptively timed learning, recognition, and movement [PDF]

open access: yes, 1995
The concepts of declarative memory and procedural memory have been used to distinguish two basic types of learning. A neural network model suggests how such memory processes work together as recognition learning, reinforcement learning, and sensory-motor
Grossberg, Stephen, Merrill, John W. L.
core   +1 more source

Highly‐Conductive and Micro‐Structured Transparent Glass Substrates for Efficient and Scalable Photoelectrochemical Applications

open access: yesAdvanced Science, EarlyView.
This work paves the way for practical photoelectrochemical water splitting devices by addressing key upscaling challenges related to substrate conductivity, absorber inhomogeneity, and mass transfer limitations. Integrated improvements in substrate engineering, material processing, device architecture, and operational conditions allow the development ...
Telmo da Silva Lopes   +7 more
wiley   +1 more source

Communication and its functions

open access: yesRussian Language Studies, 2010
The article is dedicated to the analysis of communication behaviour from the point of view of realization of self-presentation social functions, as a type of self-presentation and self-actualization.
T A Chebotnikova
doaj  

PHILOSOPHY OF VALUE-MOTIVATION COMPONENTS OF VOLUNTEER ACTIVITY: COMPARATIVE STUDY

open access: yesОсвітній дискурс
Urgency of the research. The topicality of the topic is due to the insufficient conceptualization of the philosophical understanding of the value-motivational components of volunteering within the limits of world experience and comparative analysis.
Pavlo Horinov
doaj   +1 more source

Solid Harmonic Wavelet Bispectrum for Image Analysis

open access: yesAdvanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown   +3 more
wiley   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

open access: yesAdvanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka   +3 more
wiley   +1 more source

An Investigation of University Engineering Students’ Attitudes and Motivation in Correlation to Their Identity Formation in the Learning of EFL in a Multilingual and Multicultural Context

open access: yesSAGE Open
The study investigated engineering students’ attitudes and motivation in relation to their identity formation during the learning of EFL in a multilingual and multicultural context. It adopted a Motivational Factors Questionnaire (MFQ) based on Dörnyei’s
John Peter Wappa, Ilkay Gilanlioglu
doaj   +1 more source

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