Results 101 to 110 of about 495,385 (306)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Psychophysiological Mechanisms of Coordination Component of Psychomotor Abilities of the Musicians

open access: yesПсихологическая наука и образование (2007. Online), 2017
Psychomotor abilities of the musician are implemented in performing technique and include muscle strength, endurance, speed of movements, coordination, motor memory.
Korlyakova S.G.
doaj   +1 more source

Relations between Handedness and Motor Abilities in Preschool Children [PDF]

open access: yes, 2010
Relations between laterality and motor abilities were assessed in preschool children. Study sample included 202 children aged 5–7.5 decimal years. Upper extremity usage and gesture laterality was assessed by a battery of tests and used on children ...
Gustav Bala   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Fine motor skills predict expressive, but not receptive, language abilities in minimally verbal autistic adults

open access: yesFrontiers in Language Sciences
IntroductionPrevious research suggests that the motor system plays an important role in spoken language development for children and adolescents with autism spectrum disorder (ASD).
Meredith Pecukonis   +18 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Training strategies specific to the physical education and sport in what concerns the social integration of pupils with special educational needs [PDF]

open access: yes
The training, planning and the realization of adapted physical education classes must be part of the pedagogic knowledge ensemble of the didactic frame. For every child with special educational needs it is necessary an individual approach of the training
Marin Finichiu
core   +1 more source

Changes in life-style after liver transplantation [PDF]

open access: yes, 1988
Sixty-five pediatric patients who received liver transplants between May 1981 and May 1984 were observed for as many as 5 years and examined for changes in life-style.
Belle, SH   +8 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Antibiotic use during pregnancy and neurodevelopmental outcomes of offspring in early childhood [PDF]

open access: yes, 2020
There is limited research on the effects of antibiotic use during pregnancy on neurodevelopmental outcomes of offspring in early childhood. The aim of this study was to investigate associations between antibiotic use during early pregnancy and ...
Gamache, Tressa
core  

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